Results 71 to 80 of about 1,093,427 (365)

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

Cancer Discovery, 2019
A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities including radiotherapy. Here, we demonstrate that radiotherapy induces tumor cell ferroptosis.
Xueting Lang, Michael D. Green, Wen Wang, Jiali Yu, J. E. Choi, Long Jiang, P. Liao, Jiajia Zhou, Qiang Zhang, Ania Dow, A. Saripalli, Ilona Kryczek, Shuang Wei, Wojciech Szeliga, Linda Vatan, E. Stone, G. Georgiou, M. Cieslik, D. Wahl, M. Morgan, A. Chinnaiyan, T. Lawrence, W. Zou   +22 more
semanticscholar   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Antiangiogenics and radiotherapy

Journal of Pharmacy and Pharmacology, 2008
Abstract Antiangiogenic therapies are one of the fore-runners of the new generation of anticancer drugs aimed at tumour-specific molecular targets. Up until the beginning of this century, the general opinion was that targeted agents should show antitumour activity when used as single agents.
Shannon, Aoife M., Williams, Kaye J.
openaire   +3 more sources

A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck [PDF]

, 2005
Objective: The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and
Wilkowski, R., Schalhorn, A., Dellian, M., Dühmke, Eckhart, Pachmann, S., Schymura, B.   +5 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Radiotherapy plus cetuximab or cisplatin for human papillomavirus (HPV)-positive oropharyngeal cancer: a randomized, multicenter, non-inferiority clinical trial

The Lancet, 2018
Background Patients with HPV-positive oropharyngeal squamous cell carcinoma (OPC) have high survival rates when treated with radiotherapy plus cisplatin.
M. Gillison, A. Trotti, J. Harris, A. Eisbruch, P. Harari, D. Adelstein, R. Jordan, Weiqiang Zhao, E. Sturgis, B. Burtness, J. Ridge, J. Ringash, J. Galvin, M. Yao, S. Koyfman, D. Blakaj, Mohammed A. Razaq, A. Colevas, J. Beitler, Christopher U. Jones, N. Dunlap, S. Seaward, S. Spencer, T. Galloway, J. Phan, J. Dignam, J. Dignam, Q. Le   +27 more
semanticscholar   +1 more source

Development of a linear array for intracavitary in vivo dosimetry during external beam radiotherapy and brachytherapy. [PDF]

, 2003
We present the details of a new linear array dosimeter consisting of a chain of semiconductors mounted on an ultra-thin (50 μm thick) flexible substrate and housed in an intracavitary catheter. The semiconductors, manufactured by NMRC Cork, have not been
Rogers, K., Joyce, Malcolm J., Price, R. A., Benson, C.   +3 more
core  

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Association between radiation volume and breast density for skin toxicity and breast edema after radiotherapy in breast conserving therapy of breast cancer

Radiation Oncology
Background Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of toxicity for ...
Mathias Sonnhoff, Oyur Rojin Oyur, Becker Jan-Nicklas, Hermann Robert Michael, Carl Cedric Oliver, Nitsche Mirko, Christiansen Hans, Blach Robert Maximilian   +7 more
doaj   +1 more source