Results 111 to 120 of about 1,390,389 (383)

Efficacy and Safety of Locoregional Radiotherapy With Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.

JAMA Oncology, 2020
Importance The role of locoregional radiotherapy in patients with de novo metastatic nasopharyngeal carcinoma (mNPC) is unclear. Objective To investigate the efficacy and safety of locoregional radiotherapy in de novo mNPC.
R. You, You-Ping Liu, Pei-yu Huang, X. Zou, R. Sun, Yu-Xiang He, Yishan Wu, Guo-Ping Shen, Hong-Dan Zhang, Chongyang Duan, S. Tan, Jing-yu Cao, Jibin Li, Yu-long Xie, Yi-Nuan Zhang, Zhi-qiang Wang, Qi Yang, Mei Lin, Rou Jiang, Mengxia Zhang, Y. Hua, Linquan Tang, Ai-Hua Zhuang, Qiu-Yan Chen, Ling Guo, H. Mo, Yong Chen, H. Mai, Li Ling, Qing Liu, M. Chua, Ming-Yuan Chen   +31 more
semanticscholar   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Inhibition of IKK-NFκB pathway sensitizes lung cancer cell lines to radiation

Cancer Biology & Medicine, 2017
Objective : Cancer cell radioresistance is a stumbling block in radiation therapy. The activity in the nuclear factor kappa B (NFκB) pathway correlates with anti-apoptotic mechanisms and increased radioresistance.
Avgi Tsolou, Maria Liousia, Dimitra Kalamida, Stamatia Pouliliou, Alexandra Giatromanolaki, Michael Koukourakis   +5 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Evaluation of the positional reproducibility of sedation versus non-sedation state in pediatric radiotherapy: a retrospective study

Frontiers in Oncology
ObjectiveTo assess the positional reproducibility of sedated and non-sedated pediatric tumor patients during radiotherapy through a retrospective analysis of cone-beam computed tomography (CBCT) and planned computed tomography (CT) scan data.MethodsThe ...
Zhanquan Lei, Yuequan Shi, Yiqun Liu, Bo Gao, Kongfeng Shao, Xijin Lin, Lizhen Wu, Zhaojie Yao   +7 more
doaj   +1 more source

Expanding the use of real-time electromagnetic tracking in radiation oncology. [PDF]

, 2011
In the past 10 years, techniques to improve radiotherapy delivery, such as intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT) for both inter- and intrafraction tumor localization, and hypofractionated delivery techniques ...
Kupelian, Patrick A, Meeks, Sanford L, Shah, Amish P, Willoughby, Twyla R   +3 more
core   +1 more source

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Nature Network Boston, 2018
Focal radiation therapy enhances systemic responses to anti-CTLA-4 antibodies in preclinical studies and in some patients with melanoma1–3, but its efficacy in inducing systemic responses (abscopal responses) against tumors unresponsive to CTLA-4 ...
S. Formenti, N. Rudqvist, E. Golden, B. Cooper, E. Wennerberg, C. Lhuillier, C. Vanpouille-Box, K. Friedman, Lucas Ferrari de Andrade, K. Wucherpfennig, A. Heguy, Naoko Imai, S. Gnjatic, R. Emerson, X. Zhou, Tuo Zhang, A. Chachoua, S. Demaria   +17 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

The Prognostic Significance of TMSB4X in Glioma Patients

International Journal of General Medicine
Sijie Li,1 Tianyi Fan,1 Zengyao Hao,1 Zizhou Zhang,1 Xuetao Han,1 Jiayuan Li,1 Yu Wang,1 Huandi Zhou,1– 3 Xiaoying Xue1,3 1Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ...
Li S, Fan T, Hao Z, Zhang Z, Han X, Li J, Wang Y, Zhou H, Xue X   +8 more
doaj  

MLC parameters from static fields to VMAT plans: an evaluation in a RT-dedicated MC environment (PRIMO)

Radiation Oncology, 2019
Background PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characteristics of an HD-120 MLC (Varian),
Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti, Stefano Tomatis   +9 more
doaj   +1 more source