Results 171 to 180 of about 1,390,389 (383)

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer.

New England Journal of Medicine, 2017
F. C. Hamdy, J. Donovan, J. Lane, M. Mason, C. Metcalfe, P. Holding, M. Davis, T. Peters, E. Turner, Richard M. Martin, J. Oxley, M. Robinson, J. Staffurth, E. Walsh, P. Bollina, J. Catto, A. Doble, A. Doherty, D. Gillatt, R. Kockelbergh, H. Kynaston, A. Paul, P. Powell, S. Prescott, D. Rosario, E. Rowe, D. E. Neal, D. E. Neal   +27 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

CBCT-based online adaptive radiotherapy of the bladder – geometrical and dosimetrical considerations compared to conventional IGRT

Radiation Oncology
Background Bladder cancer radiotherapy presents unique challenges due to the dynamic anatomy of the bladder and the surrounding organs. Conventional image-guided radiotherapy (IGRT) relies on fixed treatment margins and daily couch corrections, which can
Jann Fischer, Laura Anna Fischer, Jona Bensberg, Natalia Bojko, Mohamed Bouabdallaoui, Jasper Frohn, Petra Hüttenrauch, Mandy Klingebiel, Daniela Schmitt, Katharina Tegeler, Daniela Wagner, Alina Wenzel, Jessica Moldauer, Niklas Christian Scheele, Hanne Elisabeth Ammon, Stephanie Bendrich, Sandra Donath, Leif Hendrik Dröge, Manuel Guhlich, Andrea Hille, Olga Knaus, Martin Leu, Jan Oelmann, Rami El Shafie, Georg Stamm, Arndt F. Schilling, Stefan Rieken   +26 more
doaj   +1 more source

Bringing online adaptive radiotherapy to a standard C-arm linac

Physics and Imaging in Radiation Oncology
Current online adaptive radiotherapy (oART) workflows require dedicated equipment. Our aim was to develop and implement an oART workflow for a C-arm linac which can be performed using standard clinically available tools.
Maureen L. Groot Koerkamp, Gijsbert H. Bol, Petra S. Kroon, Lean L. Krikke, Tessa Harderwijk, Annelies J. Zoetelief, Annick Scheeren, Stefan van der Vegt, Annika Plat, Jochem Hes, Ineke B.A. van Gasteren, Esmee R.T. Renders, Reijer H.A. Rutgers, Saskia W. Kok, Joost van Kaam, Geja J. Schimmel-de Kogel, Gonda G. Sikkes, Dennis Winkel, Michael J. van Rijssel, André J.M. Wopereis, Kübra Ishakoglu, Juus L. Noteboom, Jochem R.N. van der Voort van Zyp, Naomi Beck, Timo F.W. Soeterik, Sandrine M.G. van de Pol, Wietse S.C. Eppinga, Corine A. van Es, Bas W. Raaymakers   +28 more
doaj   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials

The Lancet, 2005
M. Clarke, R. Collins, S. Darby, C. Davies, P. Elphinstone, V. Evans, J. Godwin, R. Gray, C. Hicks, S. James, E. Mackinnon, P. McGale, T. McHugh, R. Peto, Carolyn Taylor, Yaochen Wang   +15 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Epithelioma of External Auditory Meatus Treated by Deep Radiotherapy. No Return after Six Months [PDF]

, 1934
E. A. Peters
openalex   +1 more source