Results 41 to 50 of about 1,005,751 (338)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A prediction model for xerostomia in locoregionally advanced nasopharyngeal carcinoma patients receiving radical radiotherapy

BMC Oral Health, 2022
Background This study was to evaluate the predictors of xerostomia and Grade 3 xerostomia in locoregionally advanced nasopharyngeal carcinoma (NPC) patients receiving radical radiotherapy and establish prediction models for xerostomia and Grade 3 ...
Minying Li, Jingjing Zhang, Yawen Zha, Yani Li, Bingshuang Hu, Siming Zheng, Jiaxiong Zhou   +6 more
doaj   +1 more source

PERBEDAAN SKOR GERIATRIC DEPRESSION SCALE PADA PASIEN USIA LANJUT DENGAN KANKER KEPALA DAN LEHER YANG BELUM DAN SEDANG MENJALANI RADIOTERAPI [PDF]

, 2016
Background. There has been a constant rise in the elderly population number throughout the world, more so in the developing countries. This growth is paralleled with rapid increase in disease prevalence, head and neck cancer being one of them.
Saktini, Fanti, Sekarnegari, Gendis, Wardani, Natalia Dewi   +2 more
core  

Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer : a phase II trial [PDF]

, 2017
Background: Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC).
De Meerleer, Gert, Decaestecker, Karel, Dirix, Piet, Fonteyne, Valerie, Junius, Sara, Ost, Piet, Rammant, Elke, Swimberghe, Martijn   +7 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology - a subgroup analysis of a multicenter, phase III trial [PDF]

, 2013
Background: In a previous analysis (Int J Radiat Oncol Biol Phys 70:828-835,2010), we assessed whether an adjuvant supplementation with selenium (Se) improves Se status and reduces the radiation-induced side-effects of patients treated by adjuvant ...
Adamietz, Irenäus A., Baaske, Dieter, Berndt-Skorka, Regina, Buentzel, Jens, Eich, Hans-Theodor, Glatzel, Michael, Huebner, Jutta, Kisters, Klaus, Kundt, Guenther, Micke, Oliver, Muecke, Ralph, Prott, Franz-Josef, Reichl, Berthold, Schaefer, Ulrich, Schomburg, Lutz   +14 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Autophagic flux response and glioblastoma sensitivity to radiation

Cancer Biology & Medicine, 2018
Objective: Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human tumors. It constitutes a unique non-metastasizing human tumor model with high resistance to radiotherapy and chemotherapy.
Achilleas G. Mitrakas, Dimitra Kalamida, Alexandra Giatromanolaki, Stamatia Pouliliou, Avgi Tsolou, Rafail Kyranas, Michael I. Koukourakis   +6 more
doaj   +1 more source

Evaluating differences in respiratory motion estimates during radiotherapy: a single planning 4DMRI versus daily 4DMRI

Radiation Oncology, 2021
Background In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT).
Duncan den Boer, Johannes K. Veldman, Geertjan van Tienhoven, Arjan Bel, Zdenko van Kesteren   +4 more
doaj   +1 more source