Results 61 to 70 of about 156,116 (297)

The Birmingham Boron Neutron Capture Therapy (BNCT) project : developments towards selective internal particle therapy [PDF]

, 2011
This paper will review progress on two aspects of the Birmingham BNCT project. Firstly on evaluation of the effects of high and low LET radiations when delivered simultaneously, and secondly on attempts to optimise delivery of the boron carrier compound ...
Boddy, A., Charles, M. W., Croswell, G., Cruickshank, G. S., Detta, A., Doran, J., Elliott, M., Ford, S., Ghani, Z., Graham, N., Green, S., Halbert, G., Hill, M., James, N. D., Jones, B., King, A., Lockyer, N., Mill, A. J., Ngoga, D., Phoenix, B., Sheehan, T. M. T., Thompson, J., Vickerman, J., Wojnecki, C.   +23 more
core   +1 more source

Investigation of Chromosome 1 Aberrations in the Lymphocytes of Prostate Cancer and Benign Prostatic Hyperplasia Patients by Fluorescence in situ Hybridization

Cancer Management and Research, 2021
Justyna Miszczyk,1 Mikołaj Przydacz,2 Michał Zembrzuski,2 Piotr L Chłosta2 1Department of Experimental Physics of Complex Systems, The H. Niewodniczański Institute of Nuclear Physics PAN, Krakow, Poland; 2Department of Urology, Jagiellonian University ...
Miszczyk J, Przydacz M, Zembrzuski M, Chłosta PL   +3 more
doaj  

Analysis of Geometric Performance and Dosimetric Impact of Using Automatic Contour Segmentation for Radiotherapy Planning

Frontiers in Oncology, 2020
Purpose: To analyze geometric discrepancy and dosimetric impact in using contours generated by auto-segmentation (AS) against manually segmented (MS) clinical contours.Methods: A 48-subject prostate atlas was created and another 15 patients were used for
Minsong Cao, Bradley Stiehl, Victoria Y. Yu, Ke Sheng, Amar U. Kishan, Robert K. Chin, Yingli Yang, Dan Ruan   +7 more
doaj   +1 more source

Three-Dimensional Dose Prediction for Lung IMRT Patients with Deep Neural Networks: Robust Learning from Heterogeneous Beam Configurations

, 2019
The use of neural networks to directly predict three-dimensional dose distributions for automatic planning is becoming popular. However, the existing methods only use patient anatomy as input and assume consistent beam configuration for all patients in ...
Barragan Montero, Ana Maria, Geets, Xavier, Jiang, Steve, Lin, Mu-Han, Lu, Weiguo, Nguyen, Dan, Norouzi-Kandalan, Roya, Sterpin, Edmond   +7 more
core   +1 more source

Stereotactic Magnetic Resonance-guided Online Adaptive Radiotherapy for Oligometastatic Breast Cancer: A Case Report. [PDF]

, 2018
We present a case of durable local control achieved in a patient treated with stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) for an abdominal lymph node in the setting of oligometastatic breast cancer.
Cao, Minsong, Dang, Audrey, Lamb, James, Lee, Percy, Low, Daniel A, Raldow, Ann C, Steinberg, Michael L, Tyran, Marguerite   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Evaluation of Perkin Elmer Amorphous Silicon Electronic Portal Imaging Device for Small Photon Field Dosimetry [PDF]

Journal of Biomedical Physics and Engineering
Background: Electronic portal imaging devices (EPIDs) are applied to measure the dose and verify patients’ position.Objective: The present study aims to evaluate the performance of EPID for measuring dosimetric parameters in small photon fields.Material ...
Mohammad Haghparast, Wrya Parwaie, Mohsen Bakhshandeh, Nina Tuncel, Seied Rabi Mahdavi   +4 more
doaj   +1 more source

Treatment planning in molecular radiotherapy

Zeitschrift für Medizinische Physik, 2013
In molecular radiotherapy a radionuclide or a radioactively labelled pharmaceutical is administered to the patient. Treatment planning therefore comprises the determination of activity to administer. This administered activity should maximize tumour cell sterilization while minimizing normal tissue damage.
Gerhard, Glatting, Manuel, Bardiès, Michael, Lassmann   +2 more
openaire   +2 more sources