Results 71 to 80 of about 2,696,728 (250)

Clinical evaluation of endolymphatic radiotherapy in malignant lymphoma [PDF]

, 1974
By endolymphatic injection of radioisotope 131I.Lipiodol, so.called endolymphatic radiotherapy, we treated 10 cases with malignant lymphoma and found a marked tumor reduction to normal size in all the 10 cases we tried.
Irino, Shozo, Uno, Junichiro, Tanji, Tameyo, Oka, Akira   +3 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Data for TROTS – The Radiotherapy Optimisation Test Set [PDF]

, 2017
The Radiotherapy Optimisation Test Set (TROTS) is an extensive set of problems originating from radiotherapy (radiation therapy) treatment planning. This dataset is created for 2 purposes: (1) to supply a large-scale dense dataset to measure performance ...
Heijmen, B.J.M. (Ben), Ben Heijmen, Heijmen, Ben, Breedveld, S. (Sebastiaan), Breedveld, Sebastiaan, Sebastiaan Breedveld, Breedveld, Sebastiaan; id_orcid   +6 more
core   +2 more sources

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Spatially Configurable Conformal Sensor Integration on an Ultra‐Fine Metallic Needle for Minimally Invasive Deep‐Tissue Oxygen Monitoring

Advanced Materials Technologies, EarlyView.
A multi‐point oxygen‐sensing ultra‐fine needle (MO‐UFN) is developed by conformally integrating a lithographically patterned flexible electrochemical sensor array onto a clinical acupuncture needle. The platform preserves an approximately 0.3 mm diameter while enabling spatially resolved oxygen profiling along the insertion pathway.
Yeju Seo, Jaeho Park, Yongrok Jeong, Ji‐Hwan Ha, Junseong Ahn, Jimin Gu, Su A Park, Ilwoo Jun, Kichul Lee, Inkyu Park   +9 more
wiley   +1 more source

Dosimetric and Treatment Delivery Analysis of Volumetric Modulated Arc Therapy systems for Pharyngeal Carcinoma [PDF]

Iranian Journal of Medical Physics
Introduction: This study evaluated the dosimetric performance and delivery efficiency of three volumetric modulated arc therapy (VMAT) techniques using different multileaf collimator (MLC) systems: MLCi2, Agility and HDMLC for the treatment of pharyngeal
Srikanth Guduru, Rohith Singareddy, Madhusudhana Sresty N.V.N., Deleep Kumar Gudipudi, Aparna Dode   +4 more
doaj   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Towards rapid and efficient simulation-free radiotherapy: MR guided adaptive prostate radiotherapy on the MR-Linac using diagnostic MRI reference planning.

BACKGROUND AND PURPOSE: Simulation-free radiotherapy offers improved efficiency for adaptive treatments. This planning study presents a simulation-free pre-treatment workflow for prostate cancer online adaptive radiotherapy on a MR-Linac.
Oelfke, U, Chick, J, Alexander, S, Nill, S, Dunlop, A, Herbert, T, Cooper, S, Predescu, N, Casey, F, Lőrincz-Molnár, S-B, Tree, A   +10 more
core   +1 more source

A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial. [PDF]

, 2007
OBJECTIVES: To assess whether omission of postoperative radiotherapy in women with 'low-risk' axillary node negative breast cancer (T0-2) treated by breast-conserving surgery and endocrine therapy improves quality of life and is more cost-effective ...
van der Pol, M, Goh, TT, M van der Pol, Williams, LJ, R Lindley, Prescott, RJ, Kunkler, IH, C King, King, CC, Lindley, R, Jack, W, W Jack, I Kunkler, J Cairns, L Williams, T Goh, Cairns, J, R Prescott   +17 more
core   +1 more source