Results 51 to 60 of about 68,169 (294)

A investigación no ILG (1971–1990) e a importancia do ALGa na estandarización da lingua galega

open access: yesEstudios Hispánicos
A comezos da década de 1960 Dámaso Alonso e A. Zamora Vicente queixábanse do considerable atraso nos estudos do galego moderno. Neste artigo referireime, en primeiro lugar, á superación dese atraso con investigacións, sobre todo, do galego oral, e ...
Francisco Fernández Rei
doaj   +1 more source

Prevalence of Porphyromonas gingivalis four rag locus genotypes in patients of orthodontic gingivitis and periodontitis.

open access: yesPLoS ONE, 2013
Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis.
Yi Liu   +4 more
doaj   +1 more source

Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity. [PDF]

open access: yesPLoS ONE, 2009
BACKGROUND:The RAG encoded proteins, RAG-1 and RAG-2 regulate site-specific recombination events in somatic immune B- and T-lymphocytes to generate the acquired immune repertoire.
David H Dreyfus
doaj   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen   +5 more
wiley   +1 more source

Fag Rag Spring 1977 [PDF]

open access: yes, 1977
Issue 19 of Fag Rag, a gay liberation newspaper published in Boston, MA in the spring of 1977.https://digitalcommons.usm.maine.edu/fagrag/1014/thumbnail ...
, Fag Rag, Inc
core   +1 more source

Designing Spaces of Learning with a Child Rights Approach and Participatory Planning

open access: yesInternational Journal of Arts Architecture & Design
The paper outlines the challenges faced by street-connected children in India, particularly the lack of accurate data and the failure of governance systems to address their needs.
Mallika Gupta   +2 more
doaj   +1 more source

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

open access: yesAdvanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr   +6 more
wiley   +1 more source

Parallelism strategies as a key factor for deploying Large Language Models on consumer gpus

open access: yesСистемный анализ и прикладная информатика
The exponential growth in the size of Large Language Models (LLMs) creates significant barriers to their local deployment, primarily due to Video RAM (VRAM) shortages on single devices.
K. S. Kurochka   +2 more
doaj   +1 more source

CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

open access: yesLaboratory Animal Research, 2018
Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency (SCID) in humans.
Joo-Il Kim   +9 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

open access: yesAdvanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang   +9 more
wiley   +1 more source

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