Results 61 to 70 of about 68,169 (294)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang   +22 more
wiley   +1 more source

Aurel_AI: Automating an Institutional Help Desk Using an LLM Chatbot [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics
The Aurel_AI research project was born from the need to implement a virtual help desk for a university, providing accurate organizational information to both internal and external clients.
Diego Ordóñez-Camacho   +3 more
doaj  

Fag Rag Summer 1974 [PDF]

open access: yes, 1974
Issue 9 of Fag Rag, a gay liberation newspaper published in Boston, MA in the summer of 1974.https://digitalcommons.usm.maine.edu/fagrag/1007/thumbnail ...
Fag Rag, Inc
core  

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu   +18 more
wiley   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

open access: yesAdvanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu   +4 more
wiley   +1 more source

A Retrieval-Augmented Generation Architecture for Pepper Robot in Industrial Assistance

open access: yesRobotica & Management
This paper presents a RAG architecture for the Pepper robot to support real-time, multimodal interaction in industrial environments. By balancing local and cloud processing, the system improves task assistance, response accuracy, and user experience ...
Stelian Brad   +5 more
doaj   +1 more source

Fag Rag Winter-Spring 1974 [PDF]

open access: yes, 1974
Doube issue 7 and 8 of Fag Rag, a gay liberation newspaper published in Boston, MA in the winter-spring of 1974.https://digitalcommons.usm.maine.edu/fagrag/1006/thumbnail ...
, Fag Rag, Inc
core   +1 more source

Metasurface‐Enabled Helical Wavefront Fingerprint Metrology for Quantitative Retrieval of Liquid Optical Constants

open access: yesAdvanced Science, EarlyView.
A metasurface‐enabled helical wavefront fingerprint (MHWF) paradigm is proposed for quantitative and specific retrieval of a liquid medium's refractive index and extinction coefficient. The liquid's complex dielectric response governs the wavefront evolution of the metasurface‐generated focused vortex beam, forming a distinctive three‐dimensional ...
Yuting Zhou   +10 more
wiley   +1 more source

Fag Rag Fall-Winter 1973 [PDF]

open access: yes, 1973
Issue 6 of Fag Rag, a gay liberation newspaper published in Boston, MA in fall-winter of 1973.https://digitalcommons.usm.maine.edu/fagrag/1005/thumbnail ...
, Fag Rag, Inc
core   +1 more source

SES-RAG: An Adaptive Framework with ModernBERT Segmentation and Generative-Alignment Expansion

open access: yesApplied Sciences
Retrieval-augmented generation (RAG) is promising for long-document question answering, but its performance is often limited by fixed-window chunking, query-document mismatch, and static context truncation.
Chaobang Gao, Hao He, Qiang Zhang
doaj   +1 more source

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