Results 71 to 80 of about 68,169 (294)

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Enhancing Trust in Online Reviews: A Cross-Domain Fake Review Detection Framework Using Generative AI

Applied Computer Systems
Online reviews influence consumer decisions in e-commerce but are threatened by deceptive content. Detecting these fake reviews across domains remains challenging due to limited labelled data, class imbalance, and domain-specific bias. This work proposes
Gupta Richa, Kashyap Indu, Jindal Vinita
doaj   +1 more source

ALIMA – Ein RAG-basiertes System zur LLM-gestützten Sacherschließung: Prototypentwicklung und erste Erfahrungen aus der Praxis

Bibliothek
Die Sacherschließung von Neuerwerbungen gehört zu den zeitaufwendigen Kernaufgaben des Fachreferats an wissenschaftlichen Bibliotheken. Die Zuordnung von kontrollierten Schlagworten aus der Gemeinsamen Normdatei (GND) sowie die klassifikatorische ...
Hübler Conrad
doaj   +1 more source

RAG4DS: Retrieval-Augmented Generation for Data Spaces—A Unified Lifecycle, Challenges, and Opportunities

IEEE Access
Retrieval-Augmented Generation (RAG) has gained significant attention from many researchers as an effective solution to address the hallucination issue of Foundational Models (FMs), particularly Large Language Models (LLMs). Although the RAG framework is
Majjed Al-Qatf, Rafiqul Haque, Saeed Hamood Alsamhi, Samuele Buosi, Muhammad Asif Razzaq, Mohan Timilsina, Ammar Hawbani, Edward Curry   +7 more
doaj   +1 more source

Fag Rag November-December 1975 [PDF]

, 1975
Issue 14 of Fag Rag, a gay liberation newspaper published in Boston, MA in November-December of 1975.https://digitalcommons.usm.maine.edu/fagrag/1012/thumbnail ...
, Fag Rag, Inc
core   +1 more source

Development of retrieval-augmented generation–based large language model for drug-induced liver injury using Livertox data

Hepatology Communications
Background:. Idiosyncratic DILI is a complex clinical challenge requiring timely and accurate decision support. LiverTox, curated by the National Institute of Health (NIH), offers a comprehensive DILI evidence base, but its encyclopedia-like format ...
Ashwin Rao, George Cholankeril, Avegail Flores, Gagan Sood, Terrence E. White, Fasiha Kanwal, Hashem B. El-Serag   +6 more
doaj   +1 more source

Fag Rag Summer 1973 [PDF]

, 1973
Issue 5 of Fag Rag, a gay liberation newspaper published in Boston, MA in the summer of 1973.https://digitalcommons.usm.maine.edu/fagrag/1004/thumbnail ...
, Fag Rag, Inc
core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Fag Rag February-March 1976 [PDF]

, 1976
Issue 15 of Fag Rag, a gay liberation newspaper published in Boston, MA in the February-March of 1976.https://digitalcommons.usm.maine.edu/fagrag/1013/thumbnail ...
, Fag Rag, Inc
core   +1 more source

Improving Performance of Local Chatbot with Caching [PDF]

Journal of Systemics, Cybernetics and Informatics
Chatbots and the technology behind them are widely used in many places and in various ways. Retrieval Augmented Generation AI framework has gained its popularity by its linking of large language model with private dataset.
John Jenq
doaj