Results 181 to 190 of about 140,313 (357)

Integrated Use of Oxidative Stress and Histological Biomarkers of T. tinca as Indicators of 17‐Alpha‐Ethynylestradiol Exposure

open access: yesEnvironmental Toxicology, Volume 41, Issue 1, Page 49-67, January 2026.
ABSTRACT The potential adverse effects of 17‐alpha‐ethynylestradiol (50, 100, and 500 μg EE2/kg b.w., for 30 days) on tench ( Tinca tinca ) were evaluated by integrating biomarkers including physiological (hepato‐somatic index, spleen‐somatic index, and hematocrit), oxidative stress (catalase, glutathione peroxidase, and glutathione reductase ...
Ana L. Oropesa   +3 more
wiley   +1 more source

Naphthenic Acid-Induced ROS Emissions by Rainbow Trout Mitochondria. [PDF]

open access: yesToxics
Kalvani Z   +4 more
europepmc   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 96-112, January 2026.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

LPS-Induced Inflammation and Preconditioning in Rainbow Trout: Markers of Innate Immunity and Oxidative Stress. [PDF]

open access: yesAnimals (Basel)
Sukhovskaya IV   +7 more
europepmc   +1 more source

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

open access: yesThe FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.
We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen   +15 more
wiley   +1 more source

Novel TRIM Proteins Modulating the Innate Immune Response of Rainbow Trout (<i>Oncorhynchus mykiss</i>). [PDF]

open access: yesAnimals (Basel)
Donoso F   +9 more
europepmc   +1 more source

Residual flexibility in the topologically constrained multivalent complex between the GKAP scaffold and LC8 hub proteins

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 76-95, January 2026.
The scaffold protein GKAP and the hub protein LC8 form a well‐defined hexameric complex, with the stoichiometry of 2 GKAP : 2 LC8 dimers. NMR and molecular dynamics calculations confirm that the LC8‐binding segment of GKAP is intrinsically disordered even in the complex form.
Eszter Nagy‐Kanta   +10 more
wiley   +1 more source

Hydrophobic residues in the α‐synuclein NAC domain drive seed‐competent fibril formation and are targeted by peptide inhibitors

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 134-155, January 2026.
The hydrophobic 68GAVV71 stretch in the NAC domain of α‐synuclein is essential for nucleation, while residues 79–95 are required for fibril stability and seeding. Truncation or inhibition of 68GAVV71 prevents fibril formation, and truncation of 79–95 abolishes seeding competency, highlighting their distinct roles in α‐synuclein aggregation and ...
Viswanath Das   +13 more
wiley   +1 more source

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