Results 241 to 250 of about 134,449 (350)

Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3634-3658, July 2025.
Co‐chaperones are key elements in cellular protein quality control. They cooperate with the major heat shock proteins in folding and preventing the toxic accumulation of misfolded proteins upon exposure to stress. Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70.
Benjamin S. Rutledge   +7 more
wiley   +1 more source

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3378-3396, July 2025.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang   +5 more
wiley   +1 more source

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3397-3411, July 2025.
Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic strategies essential. This study focuses on the role of histone deacetylases (HDACs) in liver fibrosis, particularly HDAC6.
Maria Teresa Borrello   +25 more
wiley   +1 more source

Isolation, identification and characteristics of Aeromonas sobria from diseased rainbow trout (Oncorhynchus mykiss). [PDF]

open access: yesFront Microbiol
Liu LP   +8 more
europepmc   +1 more source

Critical factors for flow cytometry analysis of the brain

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3412-3429, July 2025.
The brain is difficult to analyze using flow cytometry due to its cellular complexity, high lipid content and high autofluorescence. This study explored methods to isolate brain cells for flow cytometry, revealing that protease selection and developmental stage significantly affect cell viability and yield. Autofluorescence varies across brain regions,
Mizuki Sadakata   +6 more
wiley   +1 more source

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