N-4 Alkyl cytosine derivatives synthesis: a new approach [PDF]
, 2022 The selective N-4 alkylation of cytosine plays a critical role in the synthesis of biologically active molecules. This work focuses on the development of practical reaction conditions toward a regioselective synthesis of N-4-alkyl cytosine derivatives.
Alessia Bertamino +7 more
core +3 more sources
Nanochanneled Device and Related Methods [PDF]
, 2013 A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device.
Ferrari, Mauro +7 more
core +5 more sources
Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors [PDF]
, 2010 Background XMRV (xenotropic murine leukemia virus-related virus) is the first known example of an exogenous gammaretrovirus that can infect humans. A limited number of reports suggest that XMRV is intrinsically resistant to many of the antiretroviral ...
A Adachi +65 more
core +3 more sources
Adult antiretroviral therapy guidelines 2017 [PDF]
, 2017 These guidelines are intended as an update to those published in the Southern African Journal of HIV Medicine in 2014 and the update on when to initiate antiretroviral therapy in 2015.
Carmona, Sergio +15 more
core +3 more sources
Opening the toolbox of alternative sampling strategies in clinical routine : a key-role for (LC-)MS/MS [PDF]
, 2016 A
Capiau, Sara +2 more
core +2 more sources
Patent Pooling for Promoting Access to Antiretroviral Drugs (ARVs) – A Strategic Option for India [PDF]
The current HIV/AIDS scenario in India is quite grim with an estimated 2.4 million people living with HIV/AIDS (PLHA) in 2008, just behind South Africa and Nigeria. The anti-retroviral drugs (ARVs) remain the main stay of global HIV/AIDS treatment.
Boulle A +10 more
core +2 more sources
Synthesis of Ferrocene-Oxadiazole Complexes and a Determination of Their LogD Values [PDF]
, 2016 During the drug design process, there are many different approaches that researchers can take to improve the overall efficacy of a potential drug candidate. Aside from attempting to understand how different functional groups interact with target tissues,
Gould, Grace C.
core +1 more source
Use and outcomes of contemporary combination antiretroviral therapy in people living with HIV [PDF]
, 2022 The introduction of antiretroviral therapy (ART) has transformed HIV from a fatal illness into a manageable, chronic condition. As there is currently no cure for HIV, ART, typically including three antiretroviral drugs (ARVs), is a lifelong commitment ...
Greenberg, Lauren
core
Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates [PDF]
, 2016 As α-carboxy nucleoside phosphonates (α-CNPs) have demonstrated a novel mode of action of HIV-1 reverse transcriptase inhibition, structurally related derivatives were synthesized, namely the malonate 2, the unsaturated and saturated bisphosphonates 3 ...
Arnold, Eddy +6 more
core +1 more source
Academic drug discovery: Current status and prospects [PDF]
, 2015 Introduction. The contraction in pharmaceutical drug discovery operations in the past decade has been counter-balanced by a significant rise in the number of academic drug discovery groups.
Everett, Jeremy R.
core +1 more source