Results 21 to 30 of about 481,852 (106)
Mitochondrial changes associated with viral infectious diseases in the paediatric population
Reviews in Medical Virology, Volume 31, Issue 6, November 2021., 2021 Summary Infectious diseases occur worldwide with great frequency in both adults and children, causing 350,000 deaths in 2017, according to the latest World Health Organization reports. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins into the complexes of the ...
Sonia Romero‐Cordero +4 more
wiley +1 more source
Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human
Basic &Clinical Pharmacology &Toxicology, Volume 128, Issue 3, Page 511-524, March 2021., 2021 Abstract Molidustat is an oral inhibitor of hypoxia‐inducible factor (HIF) prolyl‐hydroxylase enhancing the erythropoietin (EPO) response to HIF; it is in clinical development for the treatment of anaemia related to chronic kidney disease. The predominant role of glucuronidation for molidustat clearance (formation of N‐glucuronide metabolite M1) and ...
Dorina van der Mey +7 more
wiley +1 more source
Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs
Clinical and Translational Science, Volume 14, Issue 1, Page 20-28, January 2021., 2021 The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, not proven. A thorough literature search was conducted to source information on the pharmacological properties of 5 ...
Veronique Michaud +6 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Highly active antiretroviral therapy (HAART) is used in HIV‐infected patients. Alongside the prolongation of patients’ life, adverse side effects associated with long‐term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important.
Agnieszka Matuszewska +24 more
wiley +1 more source
Indian Journal of Pharmaceutical Education and Research, 2023 Background: Raltegravir Potassium (RTGP), a BCS class II drug used in the treatment of HIV, has minimal solubility in the aqueous medium, resulting in poor bioavailability; Further, RTGP poor dissolution and limited solubility are also major factors ...
Dani Lakshman Yarlagadda +2 more
semanticscholar +1 more source
Research, Society and Development, 2022 Integrase Inhibitors are a promising new class of antiretroviral. However, studies of these drugs in tuberculosis (TB) and, HIV/aids coinfection are scarce.
N. Resende +5 more
semanticscholar +1 more source
AIDS (London), 2022 Objective: To study gut microbiota before and 24 weeks after a single antiretroviral agent switch. Design: HIV-positive patients with efavirenz (EFV) or a protease inhibitor (PI)-based antiretroviral therapy (ART) were randomized to switch EFV or PI to ...
A. Hanttu +6 more
semanticscholar +1 more source
, 2021 Aims: To evaluate the efficacy, effectiveness, and safety of integrase inhibitors in the treatment of HIV/AIDS in patients coinfected with tuberculosis (TB). Methods: Clinical trials or observational studies were included.
N. Resende +5 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the WHO as a histological CRC with bad prognosis.
Begoña Alburquerque-González +14 more
semanticscholar +1 more source
Burkitt Lymphoma of the Duodenum: An Uncommon Phenomenon
Case Reports in Gastrointestinal Medicine, Volume 2019, Issue 1, 2019., 2019 Burkitt lymphoma is an aggressively growing tumor commonly found in African children, involving the jaw and facial bones. Most non‐Hodgkin lymphoma tumors involve extra nodal sites like the nervous system and gastrointestinal tract. A rare variant of this type of lymphoma is found in immunocompromised patients specifically in the gastrointestinal tract
Fahad Malik +3 more
wiley +1 more source