Results 81 to 90 of about 1,626 (189)

Clinical Trial: Study to Investigate the Efficacy and Safety of the Alpha‐2‐Delta Ligand PD‐217,014 in Patients With Irritable Bowel Syndrome

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 5, Page 803-813, March 2025.
The novel α2δ ligand, PD‐217,014 shows no efficacy in irritable bowel syndrome (IBS). If earlier α2δ ligands do have efficacy in reducing abdominal pain in IBS, then this efficacy does not extend to all members of this pharmacological class, whether suffering with high levels of pain and/or anxiety or not. ABSTRACT Introduction Despite the emergence of
Lesley A. Houghton, Simiao Gao, Steven A. Gilbert, Benoit Coffin, Magnus Simren, Jeremy D. Gale, the A4451007 study investigators   +6 more
wiley   +1 more source

Concordance Between Pharmaceuticals and Medical Devices Agency Review and Ministry of Health, Labour and Welfare Decision Among New Drug Applications in Japan

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 544-553, February 2025.
New drug applications (NDAs) in Japan are reviewed by the Pharmaceuticals and Medical Devices Agency (PMDA). Those that pass the review are subsequently subject to deliberation by the Ministry of Health, Labour and Welfare Pharmaceutical Affairs and Food Sanitation Councils (MHLW‐PAFSC), and the MHLW legislatively grants approval based on its positive ...
Makoto Miyazawa, Mototsugu Tanaka, Yusuke Tanaka, Ryohei Terashima, Mio Ezura, Haruna Miyazawa, Mutsuhiro Ikuma, Yoshihiko Tomita   +7 more
wiley   +1 more source

A Randomized, Double-Blind, Parallel, Comparative Study to Evaluate the Efficacy and Safety of Ramosetron Plus Dexamethasone Injection for the Prevention of Acute Chemotherapy-Induced Nausea and Vomiting

, 2011
To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy- induced nausea and vomiting. Cancer patients scheduled to receive chemotherapy containing either of the four drugs ( cisplatin, doxorubicin ...
何景良;蘇五洲;謝瑞坤;林宗哲;趙祖怡, HO, CHING-LIANG;SU, WU-CHOU;HSIEH, RUEY-KUN;LIN, ZONG-ZHE;CHAO, TSU-YI   +1 more
core   +2 more sources

Comparison of ramosetron and ondansetron for preventing postoperative nausea and vomiting following spine surgery in highly susceptible patients [PDF]

, 2008
Background: Opioid based patient-controlled analgesia (PCA) effectively provides adequate pain control after spine surgery, often at the expense of high incidence of postoperative nausea and vomiting (PONV).
심재광, 최용선, 곽영란, 박윤곤, Jae Kwang Shim, So-young Yang, Yong Seon Choi, Young Lan Kwak, Wyun Kon Park   +8 more
core   +1 more source

Microbiological and Physicochemical Stability of a mixture of fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron for Intravascular Pateint Controlled Anesthesia

, 2020
This study provides information on the stability of the drug mixture (fentanyl and one drug from oxycodone or hydromorphone, nefopam, and one from ondansetron or ramosetron), which is frequently used during intravascular patient controlled ...
Chung Hun Lee
core   +1 more source

Metabolic Fate of Ramosetron Hydrochloride. (2). Absorption, Distribution and Excretion after Oral Administration of 14C-Ramosetron Hydrochloride to Rats.

Drug Metabolism and Pharmacokinetics, 1995
The absorption, distribution and excretion of radioactivity were investigated after a single oral administration of 1 mg/kg of 14C-ramosetron hydrochloride to rats.1. Blood radioactivity levels reached the Cmax at 15 min after administration, and then decreased bi-phasically with a terminal half life (t1/2) of 2.1 hr. Plasma radioactivity levels showed
NAKAMURA, Eiji, IMASAKI, Hajime, TAKESHIGE, Tetsuo, MIURA, Hiroya, WATANABE, Takashi, HIGUCHI, Saburo   +5 more
openaire   +2 more sources

Ramosetron hydrochloride for the prevention of cancer chemotherapy induced nausea and vomiting: The Indian experience

, 2014
Background: Despite the advent of 5-HT 3 antagonists, control of delayed gastrointestinal adverse events with cancer chemotherapy is still not optimal.
Prafulla Pawar, Ravindra Mittal, Jayesh J Sanmukhani   +2 more
core   +1 more source

Prophylactic Antiemetic Efficacy of Granisetron or Ramosetron in Patients Undergoing Thyroidectomy

Asian Journal of Surgery, 2002
Thyroidectomy is associated with a high incidence of postoperative nausea and vomiting (PONV), ranging from 60% to 84%. We conducted this study to compare the antiemetic effects and safety of granisetron 20 micro g/kg and ramosetron 4 micro g/kg in patients undergoing elective thyroidectomy under standard anaesthetic technique.One hundred and thirteen ...
Lee, S.Y., Lee, J.Y., Park, S.Y., Kim, J.H., Cho, O.G., Kim, J.S., Soh, E.Y.   +6 more
openaire   +2 more sources

Overweight/bowel dysmotility crosslinking and analogous laxative actions of two edible wild fruits in obese/constipated rats

Neurogastroenterology &Motility, Volume 36, Issue 12, December 2024.
Association between overweight and intestinal dysmotility and analogous laxative effects of two edible wild fruits in obese/constipated rats. Abstract Background The prompt development of obesity/constipation is the most serious problem for both children and adults.
Soumaya Wahabi, Kais Rtibi, Chirine Brinsi, Mourad Jridi, Hichem Sebai   +4 more
wiley   +1 more source

Comparison of Ramosetron and Palonosetron for Preventing Nausea and Vomiting after Spinal Surgery: Association With ABCB1 Polymorphisms

, 2017
BACKGROUND: Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) polymorphisms may influence 5-hydroxytryptamine receptor antagonist efficacy by altering their efflux transportation.
최승호, 소사라, 송종욱, 심재광, 곽영란, 장재원   +5 more
core   +1 more source