Results 131 to 140 of about 50,228 (212)

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

Comparative analysis of RAN translation from CAG repeats within the Huntingtin coding sequence

Abstract Repeat associated non-AUG (RAN) translation is a non-canonical initiation event that occurs in the absence of a start codon in repeat expansion disorders, generating aggregation-prone proteins which may contribute to pathogenicity.
Amy Krans, Richard M. Albertson, Connor Maltby, Peter K. Todd   +3 more
openaire   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Tough, Ductile, and Strong Hard‐Soft Cementitious Composite Enabled by Multi‐Material Additive Manufacturing

Advanced Materials, EarlyView.
Drawing inspiration from the layered hard‐soft architecture found in sea sponges, this work establishes a new framework for architected cementitious composites (ACC) through multi‐material additive manufacturing (MMAM) process. The integration of mortar and elastomer phases into layered architectures enables synergistic toughening mechanisms, including
Aimane Najmeddine, Shashank Gupta, William Makinen, Zayvinn Lin, Krystal Delnoce, Reza Moini   +5 more
wiley   +1 more source

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i>-related ALS and FTD phenotypes. [PDF]

Science
Jiang X, Schaeffer L, Patni D, Russo T, Lee CZ, Aguilar C, Marques C, Jansen-West K, Hruska-Plochan M, Ray-Soni A, Lim SM, Held A, Yue M, Castellanos Otero P, Aryal S, Beaussant HDAM, Basu H, Takakuwa H, Daughrity LM, Ramesh N, Da Costa P, A A Quadros AR, Nolan M, Reyes CJF, Wheeler H, Moran LC, Griesman G, Wymann B, Trombetta BA, Lopez-De-Silanes ES, Canori M, Krishnan G, Vieira Souza Da Silva Y, Eriani G, Albers MW, Arnold SE, Song Y, Jain A, Chiu IM, Zhang YJ, Gao FB, Wainger BJ, Polymenidou M, Petrucelli L, Martin F, Lagier-Tourenne C.   +45 more
europepmc   +1 more source

Flexible Ag2Se‐Based Thermoelectrics: Fundamentals, Processing, and Device Applications

Advanced Materials, EarlyView.
Ag2Se‐based thermoelectrics are reviewed from fundamental transport mechanisms to flexible device integration. Crystal structure, defect chemistry, and band features are correlated with performance optimization strategies and scalable fabrication routes.
Jie Qin, Yuchen Yang, Huangshui Ma, Yong Du, Min Hong, Qinfei Ke   +5 more
wiley   +1 more source

Direct Synthesis of High‐Valence Protein@UiO‐66 Composites: Linking Crystallization Pathways to Protein Encapsulation

Advanced Materials, EarlyView.
This work reports a direct, biocompatible method to synthesize UiO‐66, enabling one‐step encapsulation of proteins without compromising crystallinity or activity. Using advanced in situ and ex situ techniques, the study reveals that proteins integrate concurrently with MOF growth, forming crystalline protein@UiO‐66 nanoparticles, and provide insight ...
Jesús Cases Díaz, Jana Glatz, Elisa Merced Olivas, Ramon Pons, Joseph P. Patterson, Mónica Giménez‐Marqués   +5 more
wiley   +1 more source

Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation. [PDF]

Proc Natl Acad Sci U S A
Miller SL, Green KM, Crone B, Switzenberg JA, Tank EMH, Krans A, Jansen-West K, Wieland CM, Ji EW, Petrucelli L, Barmada SJ, Boyle AP, Todd PK.   +12 more
europepmc   +1 more source

Inverse Design of Amorphous Materials With Targeted Properties

Advanced Materials, EarlyView.
AMDEN is a diffusion model framework for the inverse design of amorphous materials with targeted properties. By incorporating Hamiltonian Monte Carlo refinement into the denoising process, the framework overcomes the challenge of generating thermally relaxed disordered structures.
Jonas A. Finkler, Yan Lin, Tao Du, Jilin Hu, Morten M. Smedskjaer   +4 more
wiley   +1 more source

RNA toxicity and RAN translation in repeat expansion disorders

Folia Pharmacologica Japonica, 2017
openaire   +3 more sources