Results 191 to 200 of about 50,228 (212)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias. [PDF]

Cell Rep
Banez-Coronel M, Zu T, Aldridge M, Guo S, Ajredini R, Morrison D, Tays AB, Duvick LA, Pletnikova O, Yachnis AT, Troncoso JC, Paulson HL, McLoughlin HS, Ashizawa T, Subramony SH, Orr HT, Ranum LPW.   +16 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats. [PDF]

Nat Commun
Baud A, Saha D, Skrzypczak T, Broniarek I, Niewiadomska D, Szlachcic WJ, Borowiak M, Gudipati RK, Sobczak K.   +8 more
europepmc   +1 more source

Intron 1 of the <i>C9orf72</i> gene: The RNA that RAN. [PDF]

Proc Natl Acad Sci U S A
Hagerman PJ.
europepmc   +1 more source

Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation. [PDF]

Nucleic Acids Res
Ito H, Machida K, Fujino Y, Hasumi M, Sakamoto S, Nagai Y, Imataka H, Taguchi H.   +7 more
europepmc   +1 more source

Distinct cellular effects of myotonic dystrophy type 2 repeat-associated non-AUG tetrapeptides. [PDF]

Dis Model Mech
Marzullo M, De Simone A, Terribili M, Di Salvio M, Mengistu DY, Somma MP, D'Amico R, Canettieri G, Cestra G, Ciapponi L.   +9 more
europepmc   +1 more source

Current biomarker development in myotonic dystrophies. [PDF]

J Neurol
Larsen M, Mendelsohn DH, Kleefeld F, Meinke P, Schoser B.   +4 more
europepmc   +1 more source

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Measuring Repeat-Associated Non-AUG (RAN) Translation

2022
Expansions of short nucleotide repeats account for more than 50 neurological or neuromuscular diseases. Many repeat expansion-containing RNAs can generate toxic repeat proteins through repeat-associated non-AUG (RAN) translation in all the reading frames. Understanding how RAN translation occurs and what cellular factors regulate this process will help
Shaopeng, Wang, Shuying, Sun
openaire   +2 more sources