Results 41 to 50 of about 50,228 (212)
Exogenous polyserine and polyleucine are toxic to recipient cells
Scientific Reports, 2022 Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL).
Ryuji Owada +2 more
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Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements [PDF]
Molecular Cell, 2016 Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.
Diana C, Cox, Thomas A, Cooper
openaire +2 more sources
PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions.
PLoS ONE, 2020 Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington's disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to ...
Paige Rudich +2 more
doaj +1 more source
Scientific Reports, 2022 Repeat-associated non-AUG translation (RAN translation) is observed in transcripts that are causative for polyglutamine (polyQ) diseases and generates proteins with mono amino acid tracts such as polyalanine (polyA), polyleucine (polyL) and polyserine ...
Ryuji Owada +4 more
doaj +1 more source
Cell Reports, 2021 Summary: eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG
Chingakham Ranjit Singh +17 more
doaj +1 more source
Interplay of RAN translation and FMRP synthesis in Fragile X‐associated disorders
The FASEB Journal, 2021 Fragile X syndrome, the most common monogenic form of intellectual disability, arises from large CGG repeat expansions in the 5’UTR of FMR1 which preclude production of the Fragile X protein, FMRP.
Samantha Fernandes +2 more
openaire +1 more source
Acta Neuropathologica Communications, 2019 Co-occurrence of multiple neuropathologic changes is a common phenomenon, most prominently seen in Alzheimer’s disease (AD) and Parkinson’s disease (PD), complicating clinical diagnosis and patient management.
Amanda N. Sacino +8 more
doaj +1 more source
Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress
EMBO Molecular Medicine, 2019 Nucleotide repeat expansions (NREs) are prevalent mutations in a multitude of neurodegenerative diseases. Repeat‐associated non‐AUG (RAN) translation of these repeat regions produces mono or dipeptides that contribute to the pathogenesis of these ...
Thomas Westergard +8 more
doaj +1 more source
Nature Communications, 2018 Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to ...
Ricardos Tabet +14 more
doaj +1 more source