Results 81 to 90 of about 8,202 (265)
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
مجلة مركز بحوث التقنيات الاحيائية, 2009 All genetic alterations in the genome that predispose to the development of cancer are utmost importance in gaining a complete understanding of the exact molecular events involved in the development of tumorigenesis.
Zafir H. Ghali +5 more
doaj +1 more source
Defense heterosis as a novel plant protection strategy: From theory to breeding practice
New Plant Protection, EarlyView.Defense heterosis, the enhanced disease resistance of hybrids compared to their parents, has evolved from early observations of hybrid vigor to a novel research concept. Advances are now clarifying its diverse genetic and molecular mechanisms across various plant–pathogen interactions.
Kaiqi Xu, Xue Li, Fangfang Li
wiley +1 more source
Specific SCAR Primers for Fungi Associated with Wood Decay of Grapevine
Phytopathologia Mediterranea, 2001 RAPD (Random Amplified Polymorphic DNA) analysis, a technique based on the polymerase chain reaction, was applied to explore variation in 178 isolates of Fomitiporia punctata, 94 of Phaeomoniella chlamydospora and 34 of Phomopsis viticola, selected as ...
Angela Abbatecola +5 more
doaj +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Pesquisa Agropecuária Brasileira, 2006 Chenopodium ambrosioides L., conhecida no Brasil por suas propriedades medicinais e usada principalmente para o controle de verminoses intestinais, é pouco estudada quanto à diversidade genética.
Simone Gualberto Santos +1 more
doaj +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Analysis of genomic instability in patients with breast cancer
مجلة مركز بحوث التقنيات الاحيائية, 2010 Genomic instability resulting in multiple molecular events believed to be a driving force in the carcinogenic process. In this study, the random amplified polymorphic DNA (RAPD) technique, a simple polymerase chain reaction (PCR) based DNA polymorphism ...
Intisar H. Ahmed +5 more
doaj +1 more source
VIEW, EarlyView.Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai +11 more
wiley +1 more source
Authentication of Bulbus Fritillariae Cirrhosae by RAPD-Derived DNA Markers
Molecules, 2014 Bulbus Fritillariae is the most commonly used antitussive herb in China. Eleven species of Fritillaria are recorded as Bulbus Fritillariae in the Chinese Pharmacopoeia.
Gui-Zhong Xin +9 more
doaj +1 more source