Results 101 to 110 of about 5,047,376 (392)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Motion of inertial particles in Gaussian fields driven by an infinite-dimensional fractional Brownian motion [PDF]

, 2012
We study the motion of an inertial particle in a fractional Gaussian random field. The motion of the particle is described by Newton's second law, where the force is proportional to the difference between a background fluid velocity and the particle ...
Schöchtel, Georg
core   +1 more source

Random attractors for stochastic porous media equations perturbed by space-time linear multiplicative noise

, 2014
Unique existence of solutions to porous media equations driven by continuous linear multiplicative space-time rough signals is proven for initial data in $L^1(\mathcal {O})$ on bounded domains $\mathcal {O}$.
Gess, Benjamin
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Random attractors for stochastic retarded strongly damped wave equations with additive noise on bounded domains

Open Mathematics, 2019
In this paper we study the asymptotic behavior for a class of stochastic retarded strongly damped wave equation with additive noise on a bounded smooth domain in ℝd. We get the existence of the random attractor for the random dynamical systems associated
Jia Xiaoyao, Ding Xiaoquan
doaj   +1 more source

Random attractor of stochastic Brusselator system with multiplicative noise

, 2015
Asymptotic dynamics of stochastic Brusselator system with multiplicative noise is investigated in this work. The existence of random attractor is proved via the exponential transformation of Ornstein-Uhlenbeck process and some challenging estimates.
J. Tu, Y. You
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Upper Semicontinuity of Random Attractors for Nonautonomous Stochastic Reversible Selkov System with Multiplicative Noise

Advances in Mathematical Physics, 2019
In this paper, the existence of random attractors for nonautonomous stochastic reversible Selkov system with multiplicative noise has been proved through Ornstein-Uhlenbeck transformation.
Chunxiao Guo, Yanfeng Guo, Xiaohan Li
doaj   +1 more source

Asymptotic behavior of random coupled Ginzburg–Landau equation driven by colored noise on unbounded domains

Advances in Difference Equations, 2021
In this paper, a random coupled Ginzburg–Landau equation driven by colored noise on unbounded domains is considered, in which the nonlinear term satisfies a local Lipschitz condition.
Zhang Chen, Lingyu Li, Dandan Yang
doaj   +1 more source

Infinitely Many Stochastically Stable Attractors

, 2006
Let f be a diffeomorphism of a compact finite dimensional boundaryless manifold M exhibiting infinitely many coexisting attractors. Assume that each attractor supports a stochastically stable probability measure and that the union of the basins of ...
Alves J, Benedicks M, Bonatti C, Bonatti C, Bowen R, Kifer Y, Kifer Y, Newhouse S, Newhouse S, Palis J, Pumariño A, Ruelle D, Shub M, Sinai Ya, Takens F, Viana M, Viana M, Vítor Araújo, Young L-S   +18 more
core   +1 more source