Results 61 to 70 of about 35,932 (265)

On Koopman and Perron-Frobenius operators of random dynamical systems

ESAIM: Proceedings and Surveys, 2014
In this paper, we investigate the Koopman and the Perron-Frobenius operators of random dynamical systems in general setting. Moreover, we give some necessary and sufficient conditions for the existence of invariant densities for the ...
Hmissi Mohamed
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Compiling Probabilistic, Bio-Inspired Circuits on a Field Programmable Analog Array

Frontiers in Neuroscience, 2014
A field programmable analog array (FPAA) is presented as an energy efficiency engine: a mixed mode processor for which functions can be compiled at significantly less energy costs using noisy computing circuits.
H. Bo eMarr, Jennifer eHasler
doaj   +1 more source

A SHADOWING LEMMA FOR RANDOM DYNAMICAL SYSTEMS

Journal of Applied Analysis & Computation, 2021
Summary: This paper proves a shadowing lemma for the random dynamical systems generated by a class of random parabolic equations. We propose random versions of Newton's method and solution-tracing theory to obtain our main theorem. This result applies to \(C^1\) random dynamical systems on Banach space without assuming the corresponding map to be a ...
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Random Attractors for the Stochastic Discrete Long Wave-Short Wave Resonance Equations

Journal of Applied Mathematics, 2011
We prove the existence of the random attractor for the stochastic discrete long wave-short wave resonance equations in an infinite lattice. We prove the asymptotic compactness of the random dynamical system and obtain the random attractor.
Jie Xin, Hong Lu
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Topological dimensions of random attractors for a stochastic reaction-diffusion equation with delay

Electronic Journal of Qualitative Theory of Differential Equations
The aim of this paper is to obtain an estimation of Hausdorff as well as fractal dimensions of random attractors for a stochastic reaction-diffusion equation with delay.
Wenjie Hu, Tomas Caraballo
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source