Results 61 to 70 of about 318,514 (285)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Random Attractors for Stochastic Retarded Reaction-Diffusion Equations on Unbounded Domains

Abstract and Applied Analysis, 2013
This paper is devoted to a stochastic retarded reaction-diffusion equation on all d-dimensional space with additive white noise. We first show that the stochastic retarded reaction-diffusion equation generates a random dynamical system by transforming ...
Xiaoquan Ding, Jifa Jiang
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

New Methodology of Block Cipher Analysis Using Chaos Game

Journal of ICT Research and Applications, 2014
Block cipher analysis  covers randomness analysis and cryptanalysis. This paper proposes a new method potentially used for randomness analysis and cryptanalysis.
Budi Sulistyo, Budi Rahardjo, Dimitri Mahayana, Carmadi Machbub   +3 more
doaj  

Dynamic properties of network motifs contribute to biological network organization. [PDF]

PLoS Biology, 2005
Biological networks, such as those describing gene regulation, signal transduction, and neural synapses, are representations of large-scale dynamic systems. Discovery of organizing principles of biological networks can be enhanced by embracing the notion
Robert J Prill, Pablo A Iglesias, Andre Levchenko   +2 more
doaj   +1 more source

Scaling Properties of Weak Chaos in Nonlinear Disordered Lattices

, 2010
The Discrete Nonlinear Schroedinger Equation with a random potential in one dimension is studied as a dynamical system. It is characterized by the length, the strength of the random potential and by the field density that determines the effect of ...
Arkady Pikovsky, C. Sulem, J. L. Cardy, L. Pitaevskii, P. Sheng, Shmuel Fishman   +5 more
core   +1 more source

Random cyclic dynamical systems

Advances in Applied Mathematics, 2017
For X a finite subset of the circle and for 0 < r <= 1 fixed, consider the function f_r : X -> X which maps each point to the clockwise furthest element of X within angular distance less than 2 pi r. We study the discrete dynamical system on X generated by f_r, and especially its expected behavior when X is a large random set. We show that, as
Michał Adamaszek, Henry Adams, Francis Motta   +2 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Chaotic Itinerancy in Random Dynamical System Related to Associative Memory Models

Mathematics, 2018
We consider a random dynamical system arising as a model of the behavior of a macrovariable related to a more complicated model of associative memory. This system can be seen as a small (stochastic and deterministic) perturbation of a determinstic system
Ricardo Bioni Liberalquino, Maurizio Monge, Stefano Galatolo, Luigi Marangio   +3 more
doaj   +1 more source