Results 61 to 70 of about 18,812,776 (248)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
On Koopman and Perron-Frobenius operators of random dynamical systems
ESAIM: Proceedings and Surveys, 2014 In this paper, we investigate the Koopman and the Perron-Frobenius operators of random dynamical systems in general setting. Moreover, we give some necessary and sufficient conditions for the existence of invariant densities for the ...
Hmissi Mohamed
doaj +1 more source
Random chain recurrent sets for random dynamical systems [PDF]
Dynamical Systems, 2009 It is known by the Conley's theorem that the chain recurrent set $CR(ϕ)$ of a deterministic flow $ϕ$ on a compact metric space is the complement of the union of sets $B(A)-A$, where $A$ varies over the collection of attractors and $B(A)$ is the basin of attraction of $A$.
Chen, X., Duan, J.
openaire +3 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
, 2022 In 1964 Lochs proved a theorem on the number of continued fraction digits of a real number x that can be determined from just knowing its first n decimal digits. In 2001 this result was generalised to a dynamical systems setting by Dajani and Fieldsteel,
Verbitskiy, Evgeny +2 more
core +1 more source
Existence of Random Attractors for a p-Laplacian-Type Equation with Additive Noise
Abstract and Applied Analysis, 2011 We first establish the existence and uniqueness of a solution for a stochastic p-Laplacian-type equation with additive white noise and show that the unique solution generates a stochastic dynamical system. By using the Dirichlet forms of Laplacian and an
Wenqiang Zhao, Yangrong Li
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Compiling Probabilistic, Bio-Inspired Circuits on a Field Programmable Analog Array
Frontiers in Neuroscience, 2014 A field programmable analog array (FPAA) is presented as an energy efficiency engine: a mixed mode processor for which functions can be compiled at significantly less energy costs using noisy computing circuits.
H. Bo eMarr, Jennifer eHasler
doaj +1 more source