Results 51 to 60 of about 31,463 (266)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Conditional random matrix ensembles and the stability of dynamical systems
New Journal of Physics, 2015 Random matrix theory (RMT) has found applications throughout physics and applied mathematics, in subject areas as diverse as communications networks, population dynamics, neuroscience, and models of the banking system.
Paul Kirk +3 more
doaj +1 more source
Quantum State Tomography in Nonequilibrium Environments
Photonics, 2023 We generalize an approach to studying the quantum state tomography (QST) of open systems in terms of the dynamical map in Kraus representation within the framework of dynamic generation of informationally complete positive operator-valued measures.
Haonan Chen +6 more
doaj +1 more source
Random cyclic dynamical systems
Advances in Applied Mathematics, 2017 For X a finite subset of the circle and for 0 < r <= 1 fixed, consider the function f_r : X -> X which maps each point to the clockwise furthest element of X within angular distance less than 2 pi r. We study the discrete dynamical system on X generated by f_r, and especially its expected behavior when X is a large random set. We show that, as
Michał Adamaszek +2 more
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Anomalous correlation-induced dynamical phase transitions
Scientific Reports, 2023 The nonanalyticity of the Loschmidt echo at critical times in quantum quenched systems is termed as the dynamical quantum phase transition, extending the notion of quantum criticality to a nonequilibrium scenario.
Niaz Ali Khan +3 more
doaj +1 more source
, 2006 The concept of random dynamical system is a comparatively recent development combining ideas and methods from the well developed areas of probability theory and dynamical systems. Due to our inaccurate knowledge of the particular physical system or due to computational or theoretical limitations (lack of sufficient computational power, inefficient ...
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Upper semicontinuity of random attractors for non-compact random dynamical systems
Electronic Journal of Differential Equations, 2009 The upper semicontinuity of random attractors for non-compact random dynamical systems is proved when the union of all perturbed random attractors is precompact with probability one.
Bixiang Wang
doaj