Results 121 to 130 of about 23,664,335 (320)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
On the Effect of Random Alternating Perturbations on Hazard Rates
, 2006 We consider a model for systems perturbed by dichotomous noise, in which the hazard rate function of a random lifetime is subject to additive time-alternating perturbations described by the telegraph process.
Di Crescenzo, Antonio +1 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Effective aspects of Bernoulli randomness [PDF]
Journal of Logic and Computation, 2019 AbstractIn this paper, we study Bernoulli random sequences, i.e. sequences that are Martin-Löf random with respect to a Bernoulli measure $\mu _p$ for some $p\in [0,1]$, where we allow for the possibility that $p$ is noncomputable. We focus in particular on the case in which the underlying Bernoulli parameter $p$ is proper (i.e.
openaire +2 more sources
Random effect estimation of time-varying factors in Stock Synthesis
, 2014 Biological processes such as fishery selectivity, natural mortality, and somatic growth can vary over time, but it is challenging to estimate the magnitude of time-variation of demographic parameters in population dynamics models, particularly when using
J. Thorson, Allan C. Hicks, R. Methot
semanticscholar +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The impact of land tenure security on agricultural productivity in Ethiopia: A meta-analysis
Sustainable EnvironmentRealized land tenure security has not yet been accomplished, despite Ethiopia’s unique land tenure security that changed over time. The aim of this meta-analysis was to investigate how land tenure security affects agricultural productivity.
Mideksa Dabessa Iticha, Jiqin Han
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source