Results 111 to 120 of about 23,664,335 (320)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Modelling individual variability in habitat selection and movement using integrated step‐selection analysis

Methods in Ecology and Evolution
Integrated step‐selection analysis (ISSA) is frequently used to study habitat selection using animal movement data. Methods for incorporating random effects in ISSA have been developed, making it possible to quantify variability among animals in their ...
Nilanjan Chatterjee, David Wolfson, Dongmin Kim, Juliana Velez, Smith Freeman, Nathan M. Bacheler, Kyle Shertzer, J. Christopher Taylor, John Fieberg   +8 more
doaj   +1 more source

Sharp generalization error bounds for randomly-projected classifiers [PDF]

, 2013
We derive sharp bounds on the generalization error of a generic linear classifier trained by empirical risk minimization on randomly projected data. We make no restrictive assumptions (such as sparsity or separability) on the data: Instead we use the ...
Durrant, Robert J., Kabán, Ata
core   +3 more sources

Random design analysis of ridge regression

, 2014
This work gives a simultaneous analysis of both the ordinary least squares estimator and the ridge regression estimator in the random design setting under mild assumptions on the covariate/response distributions.
Hsu, Daniel, Kakade, Sham M., Zhang, Tong   +2 more
core   +1 more source

A random effect autologistic regression model with application to the characterization of multiple microstructure samples

, 2016
The microstructure of a material can strongly influence its properties such as strength, hardness, wear resistance, etc., which in turn play an important role in the quality of products produced from these materials.
Nailong Zhang, Qingyu Yang
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Random effects in drug dissolution

European Journal of Pharmaceutical Sciences, 2010
The deterministic models of dissolution are commonly used in pharmaceutical studies, however, experimental results point to stochastic nature of the dissolution processes. In this paper we present stochastic modifications of deterministic models using the concept of Wiener process.
Jakub, Cupera, Petr, Lansky
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

robustlmm: An R Package for Robust Estimation of Linear Mixed-Effects Models

Journal of Statistical Software, 2016
As any real-life data, data modeled by linear mixed-effects models often contain outliers or other contamination. Even little contamination can drive the classic estimates far away from what they would be without the contamination.
Manuel Koller
doaj   +1 more source