Results 91 to 100 of about 23,664,335 (320)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

On a Proper Meta-Analytic Model for Correlations [PDF]

, 1995
Combining statistical information across studies is a standard research tool in applied psychology. The most common approach in applied psychology is the fixed effects model.
Bloom, Matthew C., Erez, Amir, Wells, Martin T.   +2 more
core   +1 more source

Statistical Characterization of the State-of-Health of Lithium-Ion Batteries with Weibull Distribution Function—A Consideration of Random Effect Model in Charge Capacity Decay Estimation

, 2017
Effective prognosis of lithium-ion batteries involves the inclusion of the influences of uncertainties that can be incorporated through random effect parameters in a nonlinear mixed effect degradation model framework.
Chinedu I. Ossai, N. Raghavan
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Charged particles in random magnetic fields and the critical behavior in the fractional quantum Hall effect

, 1995
As a model for the transitions between plateaus in the fractional Quantum Hall effect we study the critical behavior of non-interacting charged particles in a static random magnetic field with finite mean value.
A. Aronov, A. Aronov, A. Lopez, A. M. M. Pruisken, B. Huckestein, B. Huckestein, B. I. Halperin, B. I. Halperin, Bodo Huckestein, D. K. K. Lee, D. Lee, D. Shahar, E. Abrahams, F. Wegner, H. Aoki, H. P. Wei, J. K. Jain, J. K. Jain, L. W. Engel, R. B. Laughlin, R. Laughlin, S. Koch, T. Kawarabayashi, T. Sugiyama, V. Kalmeyer, V. Kalmeyer, Y. Avishai   +26 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Intruder States and their Local Effect on Spectral Statistics

, 1997
The effect on spectral statistics and on the revival probability of intruder states in a random background is analysed numerically and with perturbative methods.
Brody T A, F Leyvraz, French J B, H Hernández-Saldaña, J Flores, Leyvraz F, Mehta M L, T H Seligman   +7 more
core   +1 more source