Results 71 to 80 of about 1,662,490 (267)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The impact of land tenure security on agricultural productivity in Ethiopia: A meta-analysis
Sustainable EnvironmentRealized land tenure security has not yet been accomplished, despite Ethiopia’s unique land tenure security that changed over time. The aim of this meta-analysis was to investigate how land tenure security affects agricultural productivity.
Mideksa Dabessa Iticha, Jiqin Han
doaj +1 more source
Methodology, 2020 Linear Mixed Effect Models (LMEM) have become a popular method for analyzing nested experimental data, which are often encountered in psycholinguistics and other fields.
Jungkyu Park +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Methods in Ecology and EvolutionIntegrated step‐selection analysis (ISSA) is frequently used to study habitat selection using animal movement data. Methods for incorporating random effects in ISSA have been developed, making it possible to quantify variability among animals in their ...
Nilanjan Chatterjee +8 more
doaj +1 more source
The Random Effect Transformation for Three Regularity Classes
MathematicsWe continue the analysis of the influence of the random effect transformation on the regularity of distribution functions. The paper considers three regularity classes: heavy-tailed distributions, distributions with consistently varying tails, and ...
Jonas Šiaulys +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Technological and Economic Development of EconomyForeign direct investment (FDI) legislation plays a crucial role in fetching foreign investments. The objective of this study is to measure the impact of FDI on the Western Balkans countries (WBCs) and interpret the FDI law in the said countries.
Xhemazie Ibraimi +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source