Results 81 to 90 of about 3,675,924 (300)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

1 Transistor‐Dynamic Random Access Memory as Synaptic Element for Online Learning

open access: yesAdvanced Intelligent Systems
The rapid advancements in the field of autonomous systems have led to a significant demand for artificial‐intelligence‐of‐things (AIoT) edge‐compatible neuromorphic training accelerators with continual/online learning capability.
MD Yasir Bashir   +2 more
doaj   +1 more source

Studying the Behavior of a Paperboard Box: Experiment and Finite Element Model

open access: yesVibration
In the transportation and distribution of goods, cardboard boxes are often subjected to mechanical impacts such as shocks and random vibrations, which can cause damage to the goods. In this study, static and dynamic tests on cardboard boxes were designed
Boussad Abbès   +4 more
doaj   +1 more source

Generating Random Elements of Finite Distributive Lattices [PDF]

open access: yesThe Electronic Journal of Combinatorics, 1997
This survey article describes a method for choosing uniformly at random from any finite set whose objects can be viewed as constituting a distributive lattice. The method is based on ideas of the author and David Wilson for using "coupling from the past" to remove initialization bias from Monte Carlo randomization.
openaire   +3 more sources

On the spectra and pseudospectra of a class of non-self-adjoint random matrices and operators

open access: yes, 2013
In this paper we develop and apply methods for the spectral analysis of non-selfadjoint tridiagonal infinite and finite random matrices, and for the spectral analysis of analogous deterministic matrices which are pseudo-ergodic in the sense of E.
Ratchanikorn Chonchaiya   +5 more
core   +1 more source

A priori error indicator in the transformation method for problems with geometric uncertainties [PDF]

open access: yes, 2013
Version éditeur de cette publication à l'adresse suivante : http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6514655To solve stochastic problems with geometric uncertainties, one can transform the original problem in a domain with stochastic ...
Mac, Duc Hung   +4 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

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