Results 101 to 110 of about 3,837,977 (302)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
工程科学与技术ObjectiveAccurate assessment of the strength characteristics and deformation behavior of geocell-reinforced retaining wall structures is crucial for their safety and stability during long-term service.
ZHANG Bingbing, SONG Fei
doaj
On Two Approaches to Slope Stability Reliability Assessments Using the Random Finite Element Method
Applied Sciences, 2019 The random finite element method has been increasingly used in the geotechnical community to investigate the influence of soil spatial variability and to bridge the gap between a traditional design and a reliability-based design. There are two approaches
Yajun Li +3 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Grey Wolf Optimization algorithm with random local optimal regulation and first-element dominance
Egyptian Informatics JournalDue to the classical Grey Wolf algorithm GWO does not consider the characteristics of the local information of individual in population, a novel local random optimization strategy is proposed to make up for the defect of GWO.
Xuan Yanzhuang, Xuan Shibin
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
A Discrete-Element-Based Approach to Generate Random Parameters for Soil Fatigue Models
Journal of Marine Science and EngineeringThe structural reliability of bottom-fixed offshore wind turbines is generally influenced by the dispersion of and variability in soil properties, which affect their ultimate capacity, serviceability, and both the short- and long-term fatigue.
Alessandro Tombari, Fedor Maksimov
doaj +1 more source
Deep Hankel matrices with random elements
CoRRL4DC ...
Nathan P. Lawrence +4 more
openaire +4 more sources
Relabeling of finite element meshes using a random process [PDF]
, 1972 An algorithm is presented to relabel automatically the nodes of an arbitrary finite-element mesh. The purpose of such relabeling is to reduce the bandwidth of the master stiffness matrix produced by the finite-element method.
Roberts, E., Jr.
core
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source