Results 111 to 120 of about 3,837,977 (302)
Investigating the Impact of Random Field Element Size on Soil Slope Reliability Analysis
Applied SciencesThe determination of the optimal random field element (RFE) size is crucial in soil slope reliability analysis as it governs the trade-off between precision in failure probability calculations and computational efficiency.
Jiewen Sun +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Discrete-Element-Based Approach to Generate Random Parameters for Soil Fatigue Models (article) [PDF]
The structural reliability of bottom-fixed offshore wind turbines is generally influenced by the dispersion of and variability in soil properties, which affect their ultimate capacity, serviceability, and both the short- and long-term fatigue.
F Maksimov (19346357) +1 more
core +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Virtual testing of post-buckling behaviour of metallic stiffened panel [PDF]
, 2011 The aim of the project presented in this thesis is to demonstrate a modelling method for predicting the variability in the ultimate load of stiffened panel under axial compression due to manufacturing variability.
Wang, Yang
core +2 more sources
Higher order Perturbation Stochastic Finite Element Method of the Linear elastic Structure
工程科学与技术, 2014 :Computational precision and error control are very important to the numerical computation of the stochastic finite element method.Based on theory of random fields and perturbation finite element method,computational formulas of expected values and nth ...
廖光明, 陈兵, 王遂泸
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source