Results 121 to 130 of about 3,837,977 (302)

Structural Reliability Analysis Using Stochastic Finite Element Method Based on Krylov Subspace

Algorithms
The stochastic finite element method is an important tool for structural reliability analysis. In order to improve the calculation efficiency, a stochastic finite element method based on the Krylov subspace is proposed for the static reliability analysis
Jianyun Huang, Qiuwei Yang, Hongfei Cao, Jiwei Ma   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Degradation of the compressive strength of unstiffened/stiffened steel plates due to both-sides randomly distributed corrosion wastage

Latin American Journal of Solids and Structures
The paper addresses the problem of the influence of randomly distributed corrosion wastage on the collapse strength and behaviour of unstiffened/stiffened steel plates in longitudinal compression.
Zorareh Hadj Mohammad, Esmaeil Nouri, Mohammad Reza Khedmati, Mohammad Mahdi Roshanali   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Limit theorems for the Estermann zeta-function. II

Open Mathematics, 2005
Laurinčikas Antanas
doaj   +1 more source

Efficient and conservative estimation reliability analysis of strip footing on spatially variable c - ϕ soil using random finite element limit analysis

Studia Geotechnica et Mechanica
The study deals with reliability analysis of strip foundation on spatially variable c - ϕ soil. The spatial variability of soil strength parameters, namely cohesion c and friction angle ϕ is modelled using anisotropic uncorrelated random fields ...
Szabowicz Hubert, Kawa Marek, Puła Wojciech   +2 more
doaj   +1 more source

Data-driven homogenisation of the response of heterogeneous ductile solids with isotropic damage

Materials & Design
We propose a computational procedure to derive a data-driven surrogate constitutive model capturing the elastic–plastic response and progressive damage of a heterogeneous solid.
Weijian Ge, Vito L. Tagarielli
doaj   +1 more source

Coloring graphs from random lists of fixed size

, 2014
Let G = G(n) be a graph on n vertices with maximum degree bounded by some absolute constant Delta. Assign to each vertex v of G a list L(v) of colors by choosing each list uniformly at random from all k-subsets of a color set C of size sigma(n).
Casselgren, Carl Johan,, Casselgren, Carl Johan, Carl Johan Casselgren   +2 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source