Results 121 to 130 of about 3,675,924 (300)

Structural Reliability Analysis Using Stochastic Finite Element Method Based on Krylov Subspace

Algorithms
The stochastic finite element method is an important tool for structural reliability analysis. In order to improve the calculation efficiency, a stochastic finite element method based on the Krylov subspace is proposed for the static reliability analysis
Jianyun Huang, Qiuwei Yang, Hongfei Cao, Jiwei Ma   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Degradation of the compressive strength of unstiffened/stiffened steel plates due to both-sides randomly distributed corrosion wastage

Latin American Journal of Solids and Structures
The paper addresses the problem of the influence of randomly distributed corrosion wastage on the collapse strength and behaviour of unstiffened/stiffened steel plates in longitudinal compression.
Zorareh Hadj Mohammad, Esmaeil Nouri, Mohammad Reza Khedmati, Mohammad Mahdi Roshanali   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Limit theorems for the Estermann zeta-function. II

Open Mathematics, 2005
Laurinčikas Antanas
doaj   +1 more source

Efficient and conservative estimation reliability analysis of strip footing on spatially variable c - ϕ soil using random finite element limit analysis

Studia Geotechnica et Mechanica
The study deals with reliability analysis of strip foundation on spatially variable c - ϕ soil. The spatial variability of soil strength parameters, namely cohesion c and friction angle ϕ is modelled using anisotropic uncorrelated random fields ...
Szabowicz Hubert, Kawa Marek, Puła Wojciech   +2 more
doaj   +1 more source

Data-driven homogenisation of the response of heterogeneous ductile solids with isotropic damage

Materials & Design
We propose a computational procedure to derive a data-driven surrogate constitutive model capturing the elastic–plastic response and progressive damage of a heterogeneous solid.
Weijian Ge, Vito L. Tagarielli
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Dynamic Analysis of a Vehicle–Bridge System Under Excitation of Random Road Irregularities

Buildings
This paper presents a comprehensive study of the dynamic response analysis of vehicle–bridge coupled systems, with detailed simulation methods for the vehicles, bridges, and wheel–road coupling relationships.
Yue Zhang, Jiali Duan, Yongdou Liu, Zhidong Chen, Yangui Su, Shanyong Liu   +5 more
doaj   +1 more source