Results 121 to 130 of about 1,762,172 (296)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Dynamic Analysis of a Vehicle–Bridge System Under Excitation of Random Road Irregularities

Buildings
This paper presents a comprehensive study of the dynamic response analysis of vehicle–bridge coupled systems, with detailed simulation methods for the vehicles, bridges, and wheel–road coupling relationships.
Yue Zhang, Jiali Duan, Yongdou Liu, Zhidong Chen, Yangui Su, Shanyong Liu   +5 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Symmetrization and decoupling of combinatorial random elements

Statistics & Probability Letters, 1998
Symmetrization and decoupling are proved to be powerful tools in obtaining moment and tail inequalities for certain stochastic processes. The present note deals with independent stochastic processes on some index set \(I\) (or just real random variables) and provides, for a broad class of convex functions on \(\mathbb{R}^I\), some symmetrization and ...
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Limit theorems for the Estermann zeta-function. II

Open Mathematics, 2005
Laurinčikas Antanas
doaj   +1 more source

Efficient and conservative estimation reliability analysis of strip footing on spatially variable c - ϕ soil using random finite element limit analysis

Studia Geotechnica et Mechanica
The study deals with reliability analysis of strip foundation on spatially variable c - ϕ soil. The spatial variability of soil strength parameters, namely cohesion c and friction angle ϕ is modelled using anisotropic uncorrelated random fields ...
Szabowicz Hubert, Kawa Marek, Puła Wojciech   +2 more
doaj   +1 more source

Analysis and Prediction of Deformation of Shield Tunnel Under the Influence of Random Damages Based on Deep Learning

Buildings
Shield tunnels in operation are often affected by complex geological conditions, environmental factors, and structural aging, leading to cumulative damage in the segments and, consequently, increased deformation that compromises structural safety.
Xiaokai Niu, Yuqiang Pan, Wei Li, Zhitian Xie, Wei Song, Chengping Zhang   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The time evolution of permutations under random stirring

, 2006
We consider permutations of $\{1,...,n\}$ obtained by $\lfloor\sqrt{n}t\rfloor$ independent applications of random stirring. In each step the same marked stirring element is transposed with probability $1/n$ with any one of the $n$ elements.
Vető, Bálint
core