Results 91 to 100 of about 1,762,172 (296)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
An Alternative Sense of Asymptotic Efficiency [PDF]
The paper studies the asymptotic efficiency and robustness of hypothesis tests when models of interest are defined in terms of a weak convergence property.
Mueller, Ulrich
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Grey Wolf Optimization algorithm with random local optimal regulation and first-element dominance
Egyptian Informatics JournalDue to the classical Grey Wolf algorithm GWO does not consider the characteristics of the local information of individual in population, a novel local random optimization strategy is proposed to make up for the defect of GWO.
Xuan Yanzhuang, Xuan Shibin
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
工程科学与技术ObjectiveAccurate assessment of the strength characteristics and deformation behavior of geocell-reinforced retaining wall structures is crucial for their safety and stability during long-term service.
ZHANG Bingbing, SONG Fei
doaj
Finite element based fatigue analysis of 6082 Aluminum alloy under random loading
Journal of Materials and Engineering Structures, 2018 Mechanical and structural components are subject in the most cases during their services to random loading. For this reason, it is necessary to reduce the complex history of these kinds of loading in a series of constant amplitude cycles.
Habib KHELLAFI +6 more
doaj
On Two Approaches to Slope Stability Reliability Assessments Using the Random Finite Element Method
Applied Sciences, 2019 The random finite element method has been increasingly used in the geotechnical community to investigate the influence of soil spatial variability and to bridge the gap between a traditional design and a reliability-based design. There are two approaches
Yajun Li +3 more
doaj +1 more source
On solving systems of random linear disequations [PDF]
, 2007 An important subcase of the hidden subgroup problem is equivalent to the shift problem over abelian groups. An efficient solution to the latter problem would serve as a building block of quantum hidden subgroup algorithms over solvable groups.
Ivanyos, Gabor
core +2 more sources