Results 51 to 60 of about 21,293 (257)

Self-mixing interferometry and near-field nanoscopy in quantum cascade random lasers at terahertz frequencies

Nanophotonics, 2021
We demonstrate that electrically pumped random laser resonators, operating at terahertz (THz) frequencies, and comprising a quantum cascade laser heterostructure, can operate as sensitive photodetectors through the self-mixing effect.
Reichel Kimberly S., Pogna Eva Arianna Aurelia, Biasco Simone, Viti Leonardo, Di Gaspare Alessandra, Beere Harvey E., Ritchie David A., Vitiello Miriam S.   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Smoothed-cubic spin-glass model of random lasers

SciPost Physics
We study the equilibrium glassy behavior of a multimode random laser model with nonlinear four-body quenched disordered interactions and a global smoothed-cubic constraint on mode intensities.
Marcello Benedetti, Luca Leuzzi
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Correlated Random Bit Generation Using Chaotic Semiconductor Lasers Under Unidirectional Optical Injection

IEEE Photonics Journal, 2017
Correlated random bit generation is investigated using three optically injected chaotic semiconductor lasers. Based on a rate-equation model, a continuous-wave injection first perturbs a common laser into chaos.
Xiao-Zhou Li, Song-Sui Li, Sze-Chun Chan
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Nd:YVO₄ Random Laser with Preferential Emission at 1340 nm over 1064 nm

Photonics
Neodymium-doped yttrium vanadate random lasers have presented exceptional efficiency and output power at the 1064 nm emission wavelength. However, emission at 1340 nm has not yet been observed for these random lasers, even though regular bulk lasers have
Jessica Dipold, Luciana R. P. Kassab, Niklaus U. Wetter   +2 more
doaj   +1 more source

Multi-parameter sensor based on random fiber lasers

AIP Advances, 2016
We demonstrate a concept of utilizing random fiber lasers to achieve multi-parameter sensing. The proposed random fiber ring laser consists of an erbium-doped fiber as the gain medium and a random fiber grating as the feedback.
Yanping Xu, Mingjiang Zhang, Ping Lu, Stephen Mihailov, Xiaoyi Bao   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source