Results 51 to 60 of about 1,852,020 (244)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exploring the potential of random lasers for vortex beam generation and image edge enhancements [PDF]

APL Photonics
Vortex beams, characterized by their unique property of carrying orbital angular momentum, hold significant promise for applications in cutting-edge fields, such as high-capacity optical communications, information encryption, and super-resolution ...
Liming Gao, Lihailiang Xu, Wenzhi Wang, Xianlong Liu, Yangjian Cai, Yuan Wan   +5 more
doaj   +1 more source

One-dimensional, surface emitting, disordered Terahertz lasers

APL Photonics, 2020
Quantum cascade lasers are, by far, the most compact, powerful, and spectrally pure sources of radiation at terahertz frequencies, and, as such, they are of crucial importance for applications in metrology, spectroscopy, imaging, and astronomy, among ...
Luca Salemi, Katia Garrasi, Simone Biasco, Teresa Crisci, Harvey E. Beere, David A. Ritchie, Miriam S. Vitiello   +6 more
doaj   +1 more source

Self-mixing interferometry and near-field nanoscopy in quantum cascade random lasers at terahertz frequencies

Nanophotonics, 2021
We demonstrate that electrically pumped random laser resonators, operating at terahertz (THz) frequencies, and comprising a quantum cascade laser heterostructure, can operate as sensitive photodetectors through the self-mixing effect.
Reichel Kimberly S., Pogna Eva Arianna Aurelia, Biasco Simone, Viti Leonardo, Di Gaspare Alessandra, Beere Harvey E., Ritchie David A., Vitiello Miriam S.   +7 more
doaj   +1 more source

Optofluidic random laser [PDF]

Applied Physics Letters, 2012
Random lasing is reported in a dye-circulated structured polymeric microfluidic channel. The role of disorder, which results from limited accuracy of photolithographic process, is demonstrated by the variation of the emission spectrum with local-pump position and by the extreme sensitivity to a local perturbation of the structure. Thresholds comparable
Shivakiran Bhaktha, B. N., Bachelard, Nicolas, Noblin, Xavier, Sebbah, Patrick   +3 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Discrete mode lasers for applications in access networks [PDF]

, 2007
Fast development of the modern telecommunication networks such as fiber-to-the-home or radio-over-fiber systems require an inexpensive yet reliable optical transmitter for electro-optic conversion.
Kelly, Brian, Anandarajah, Prince M., J. O'Gorman, A. Kaszubowska-Anandarajah, O'Gorman, J., P. Anandarajah, Barry, Liam P., Guignard, Celine, O\u27Gorman, J., C. Guignard, Kaszubowska-Anandarajah, Aleksandra, B. Kelly, O'Gorman, James, L. Barry   +13 more
core   +2 more sources

Decomposed Entropy and Estimation of Output Power in Deformed Microcavity Lasers

Entropy, 2022
Park et al. showed that the Shannon entropy of the probability distribution of a single random variable for far-field profiles (FFPs) in deformed microcavity lasers can efficiently measure the directionality of deformed microcavity lasers. In this study,
Kyu-Won Park, Kwon-Wook Son, Chang-Hyun Ju, Kabgyun Jeong   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Are random lasers really random?

Journal of Applied Physics
Randomness may be intractable and could hamper human beings from discovering underlying rules. Yet, somehow, large amounts of randomness can bring about grand patterns in nature. Randomness truly underpins human curiosity to understand the truth. Random lasers, as one of the paradigms of disordered photonics, feature chaotic lasing behavior. Due to the
Yun-Tzu Hsu, Yi-Zih Chen, Yen-Yu Lin, Yu-Ming Liao, Hsia-Yu Lin, Wei-Cheng Liao, Wei-Ju Lin, Cheng-Fu Hou, Hsu-Yen Lee, Yang-Fang Chen   +9 more
openaire   +1 more source