Results 81 to 90 of about 624,831 (326)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

PACE: Redundancy Engineering in RLNC for Low-Latency Communication

IEEE Access, 2017
Random linear network coding (RLNC) is attractive for data transfer as well as data storage and retrieval in complex and unreliable settings. The existing systematic RLNC approach first sends all source symbols in a generation without encoding followed ...
Sreekrishna Pandi, Frank Gabriel, Juan A. Cabrera, Simon Wunderlich, Martin Reisslein, Frank H. P. Fitzek   +5 more
doaj   +1 more source

Expected security performance of random linear binary codes in syndrome coding [PDF]

IET Communications, 2018
In this study, random codes are applied to the classical syndrome coding scheme to achieve secrecy of communications. By analysing the effect of the values of the columns of the parity check matrix on the resulting security level of communications, a code design method is presented which constructs a class of random codes, termed random permutation ...
Ke Zhang 0027, Martin Tomlinson, Mohammed Zaki Ahmed, Xiaolin Ma   +3 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

SpaRec: Sparse Systematic RLNC Recoding in Multi-Hop Networks

IEEE Access, 2021
Sparse Random Linear Network Coding (RLNC) reduces the computational complexity of the RLNC decoding through a low density of the non-zero coding coefficients, which can be achieved through sending uncoded (systematic) packets.
Elif Tasdemir, Mate Tomoskozi, Juan A. Cabrera, Frank Gabriel, Dongho You, Frank H. P. Fitzek, Martin Reisslein   +6 more
doaj   +1 more source

Linear-Complexity Overhead-Optimized Random Linear Network Codes

CoRR, 2013
Sparse random linear network coding (SRLNC) is an attractive technique proposed in the literature to reduce the decoding complexity of random linear network coding. Recognizing the fact that the existing SRLNC schemes are not efficient in terms of the required reception overhead, we consider the problem of designing overhead-optimized SRLNC schemes. To
Kaveh Mahdaviani, Raman Yazdani, Masoud Ardakani   +2 more
openaire   +2 more sources

Improved delay estimates for a queueing model for random linear coding for unicast [PDF]

2009 IEEE International Symposium on Information Theory, 2009
Consider a lossy communication channel for unicast with zero-delay feedback. For this communication scenario, a simple retransmission scheme is optimum with respect to delay.
M. Ravanbakhsh, Á. Barbero, Øyvind Ytrehus   +2 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Caterpillar RLNC (CRLNC): A Practical Finite Sliding Window RLNC Approach

IEEE Access, 2017
Random linear network coding (RLNC) is a popular coding scheme for improving communication and content distribution over lossy channels. For packet streaming applications, such as video streaming and general IP packet streams, recent research has shown ...
Simon Wunderlich, Frank Gabriel, Sreekrishna Pandi, Frank H. P. Fitzek, Martin Reisslein   +4 more
doaj   +1 more source