Results 51 to 60 of about 801,980 (275)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Interacting Brownian motions in infinite dimensions related to the origin of the spectrum of random matrices

Modern Stochastics: Theory and Applications, 2022
The generalised sine random point field arises from the scaling limit at the origin of the eigenvalues of the generalised Gaussian ensembles. We solve an infinite-dimensional stochastic differential equation (ISDE) describing an infinite number of ...
Yosuke Kawamoto
doaj   +1 more source

Random polynomials, random matrices, and $L$-functions

, 2006
We show that the Circular Orthogonal Ensemble of random matrices arises naturally from a family of random polynomials. This sheds light on the appearance of random matrix statistics in the zeros of the Riemann zeta-function.Comment: Added background ...
David W Farmer, Dunnage J E A, Farahmand K, Farmer D W Koutsoliotas S, Farmer D W Lemurell S, Francesco Mezzadri, Hejhal D A, Iwaniec H, Iwaniec H, Katz N M, Keating J P, Mehta M L, Montgomery H L, Nina C Snaith, Odlyzko A M, Petersen K Sinclair C, Rubinstein M, Sinclair C, Sommers H J, Weyl H   +19 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Credit Risk Meets Random Matrices: Coping with Non-Stationary Asset Correlations

Risks, 2018
We review recent progress in modeling credit risk for correlated assets. We employ a new interpretation of the Wishart model for random correlation matrices to model non-stationary effects.
Andreas Mühlbacher, Thomas Guhr
doaj   +1 more source

Independence Characterization for Wishart and Kummer Random Matrices

Revstat Statistical Journal, 2020
We generalize the following univariate characterization of the Kummer and Gamma distributions to the cone of symmetric positive definite matrices: let X and Y be independent, non-degenerate random variables valued in (0,∞), then U = Y /(1 +X) and V = X ...
Bartosz Ko lodziejek , Agnieszka Piliszek   +1 more
doaj   +1 more source

Stieltjes Transforms and R-Transforms Associated with Two-Parameter Lambert–Tsallis Functions

Entropy, 2023
In this paper, we study a two-parameter family of Stieltjes transformations related to holomorphic Lambert–Tsallis functions, which are a two-parameter generalization of the Lambert function.
Hideto Nakashima, Piotr Graczyk
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Testing of random matrices [PDF]

, 2011
Let $n$ be a positive integer and $X = [x_{ij}]_{1 \leq i, j \leq n}$ be an $n \times n$\linebreak \noindent sized matrix of independent random variables having joint uniform distribution $$\hbox{Pr} {x_{ij} = k \hbox{for} 1 \leq k \leq n} = \frac{1}{n} \
Iványi, Antal, Kátai, Imre
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source