Results 71 to 80 of about 167,620 (262)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Note on Matrices of Random Numbers
Psychological Reports, 2000 The statistical and structural characteristics of 13 matrices of random numbers in which both the cells and the entries were randomly chosen are discussed. Each matrix was explored considering row means, standard deviations, and correlations as well as column means, standard deviations, and correlations. A study concerning the sequential arrangement of
Rimoldi, Horacio J. A. +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Expected Norm of Random Matrices [PDF]
Combinatorics, Probability and Computing, 2000 We compare the Euclidean operator norm of a random matrix with the Euclidean norm of its rows and columns. In the first part of this paper, we show that if A is a random matrix with i.i.d. zero mean entries, then E∥A∥h [les ] Kh (E maxi ∥ai[bull ] ∥h + E maxj ∥aj[bull ] ∥h), where K is a constant which does not depend on the dimensions or ...
openaire +3 more sources
1/2 BPS structure constants and random matrices
Journal of High Energy Physics, 2023 We study three point functions of half BPS operators in N $$ \mathcal{N} $$ = 4 super Yang-Mills theory focusing on correlators of two of the operators with dimension of order ∆ ~ N 2 and a light single trace operator.
Adolfo Holguin
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Random matrices: Probability of normality
Advances in Mathematics, 2019 In this paper, we investigate the following question: How often is a random matrix normal? We consider a random $n\times n$ matrix, $M_n$, whose entries are i.i.d. Rademacher random variables (taking values $\{ \pm1 \}$ with probability $1/2$) and prove $$2^{-\left(0.5+o(1)\right)n^2} \le P\left(M_n \text{ is normal}\right) \le 2^{-(0.302+o(1))n^{2}}. $
Deneanu, Andrei, Vu, Van
openaire +4 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
On the Maximum Probability of Full Rank of Random Matrices over Finite Fields
MathematicsThe problem of determining the conditions under which a random rectangular matrix is of full rank is a fundamental question in random matrix theory, with significant implications for coding theory, cryptography, and combinatorics. In this paper, we study
Marija Delić, Jelena Ivetić
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source