Results 71 to 80 of about 801,980 (275)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
RANDOM MATRICES: THE CIRCULAR LAW [PDF]
Communications in Contemporary Mathematics, 2008 Let x be a complex random variable with mean zero and bounded variance σ2. Let Nn be a random matrix of order n with entries being i.i.d. copies of x. Let λ1, …, λn be the eigenvalues of [Formula: see text]. Define the empirical spectral distributionμn of Nn by the formula [Formula: see text] The following well-known conjecture has been open since ...
Tao, Terence, Van, Vu
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Realistic Many-Body Quantum Systems vs. Full Random Matrices: Static and Dynamical Properties
Entropy, 2016 We study the static and dynamical properties of isolated many-body quantum systems and compare them with the results for full random matrices. In doing so, we link concepts from quantum information theory with those from quantum chaos.
Eduardo Jonathan Torres-Herrera +3 more
doaj +1 more source
The limiting spectral distribution in terms of spectral density
, 2016 For a large class of symmetric random matrices with correlated entries, selected from stationary random fields of centered and square integrable variables, we show that the limiting distribution of eigenvalue counting measure always exists and we ...
Peligrad, Costel, Peligrad, Magda
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
1/2 BPS structure constants and random matrices
Journal of High Energy Physics, 2023 We study three point functions of half BPS operators in N $$ \mathcal{N} $$ = 4 super Yang-Mills theory focusing on correlators of two of the operators with dimension of order ∆ ~ N 2 and a light single trace operator.
Adolfo Holguin
doaj +1 more source
Gaussian Fluctuation in Random Matrices
, 1994 Let $N(L)$ be the number of eigenvalues, in an interval of length $L$, of a matrix chosen at random from the Gaussian Orthogonal, Unitary or Symplectic ensembles of ${\cal N}$ by ${\cal N}$ matrices, in the limit ${\cal N}\rightarrow\infty$.
A. Selberg +15 more
core +2 more sources