Results 61 to 70 of about 1,191,216 (267)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Research on Chinese Stock Market during COVID-19—Based on Random Matrix Theory

open access: yesComplexity, 2023
This paper focuses on the three industries that are greatly impacted by COVID-19, including the consumption industry, the pharmaceutical industry, and the financial industry.
Wu Yaojie, Fang Tianhui
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Asymptotic Analysis of Large Cooperative Relay Networks Using Random Matrix Theory

open access: yesEURASIP Journal on Advances in Signal Processing, 2008
Cooperative transmission is an emerging communication technology that takes advantage of the broadcast nature of wireless channels. In cooperative transmission, the use of relays can create a virtual antenna array so that multiple-input/multiple-output ...
H. Poor, Z. Han, Husheng Li
doaj   +1 more source

The geometry of evolved community matrix spectra

open access: yesScientific Reports, 2022
Random matrix theory has been applied to food web stability for decades, implying elliptical eigenvalue spectra and that large food webs should be unstable.
Silja Borring Låstad, Jan O. Haerter
doaj   +1 more source

Gravity without averaging

open access: yesSciPost Physics, 2022
We present a gravitational theory that interpolates between JT gravity, and a gravity theory with a fixed boundary Hamiltonian. For this, we consider a matrix integral with the insertion of a Gaussian with variance $\sigma^2$, centered around a matrix
Andreas Blommaert, Jorrit Kruthoff
doaj   +1 more source

QUANTUM DYNAMICS AND RANDOM MATRIX THEORY [PDF]

open access: yesLattice Statistics and Mathematical Physics, 2002
We compute the survival probability of an initial state, with an energy in a certain window, by means of random matrix theory. We determine its probability distribution and show that is is universal, i.e. characterised only by the symmetry class of the hamiltonian and independent of the initial state.
openaire   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Large-$N_c$ gauge theory and chiral random matrix theory

open access: yes, 2013
We discuss how the $1/N_c$ expansion and the chiral random matrix theory ($\chi$RMT) can be used in the study of large-$N_c$ gauge theories. We first clarify the parameter region in which each of these two approaches is valid: while the fermion mass $m ...
Hanada, Masanori   +2 more
core   +1 more source

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