Results 61 to 70 of about 138,052 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Asymptotic Analysis of Large Cooperative Relay Networks Using Random Matrix Theory

open access: yesEURASIP Journal on Advances in Signal Processing, 2008
Cooperative transmission is an emerging communication technology that takes advantage of the broadcast nature of wireless channels. In cooperative transmission, the use of relays can create a virtual antenna array so that multiple-input/multiple-output ...
H. Poor, Z. Han, Husheng Li
doaj   +1 more source

N $$ \mathcal{N} $$ = 2 JT supergravity and matrix models

open access: yesJournal of High Energy Physics, 2023
Generalizing previous results for N $$ \mathcal{N} $$ = 0 and N $$ \mathcal{N} $$ = 1, we analyze N $$ \mathcal{N} $$ = 2 JT supergravity on asymptotically AdS2 spaces with arbitrary topology and show that this theory of gravity is dual, in a holographic
Gustavo J. Turiaci, Edward Witten
doaj   +1 more source

Gravity without averaging

open access: yesSciPost Physics, 2022
We present a gravitational theory that interpolates between JT gravity, and a gravity theory with a fixed boundary Hamiltonian. For this, we consider a matrix integral with the insertion of a Gaussian with variance $\sigma^2$, centered around a matrix
Andreas Blommaert, Jorrit Kruthoff
doaj   +1 more source

Interpolation between Airy and Poisson statistics for unitary chiral non-Hermitian random matrix ensembles

open access: yes, 2010
We consider a family of chiral non-Hermitian Gaussian random matrices in the unitarily invariant symmetry class. The eigenvalue distribution in this model is expressed in terms of Laguerre polynomials in the complex plane.
Akemann, G   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The geometry of evolved community matrix spectra

open access: yesScientific Reports, 2022
Random matrix theory has been applied to food web stability for decades, implying elliptical eigenvalue spectra and that large food webs should be unstable.
Silja Borring Låstad, Jan O. Haerter
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Singular random matrix decompositions: distributions. [PDF]

open access: yes, 2002
Assuming that Y has a singular matrix variate elliptically contoured distribution with respect to the Hausdorff measure, the distributions of several matrices associated to QR, modified QR, SV and Polar decompositions of matrix Y are determined, for ...
González Farías, Graciela   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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