Results 101 to 110 of about 2,028,751 (264)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

TRIM: AI Guided Random Number Generation for Resource-Constrained IoT Systems

IEEE Access
Random numbers often serve as the backbone for many security solutions in diverse domains such as cryptography, side channel leakage prevention, and moving target defense. However, generating true random numbers requires a physical source of entropy (e.g.
Tasneem Suha, Md Hafizur Rahman, Ashley E. Rice, Colin Smith, Rima Asmar Awad, Prabuddha Chakraborty   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

High-Speed and Scalable Quantum Random Number Generation Using InGaN Micro-LEDs

IEEE Photonics Journal
This paper presents a high-speed and scalable quantum random number generator (QRNG) based on InGaN micro-LED arrays. While traditional QRNG systems face limitations in data rate and integration complexity, our approach leverages the intrinsic quantum ...
Fu-He Hsiao, Yun-Han Chang, Hung Chou, Ching-Chang Hsiao, Boon S. Ooi, Chun-Liang Lin, Chi-Wai Chow, Yu-Heng Hong, Hao-Chung Kuo   +8 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Random Number Generation Based on Heterogeneous Entropy Sources Fusion in Multi-Sensor Networks. [PDF]

Sensors (Basel), 2023
Zhang J, Wu M.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Quantum random number generation using an on-chip nanowire plasmonic waveguide

New Journal of Physics
Quantum random number generators employ the inherent randomness of quantum mechanics to generate truly unpredictable random numbers, which are essential in cryptographic applications.
C Strydom, S Soleymani, Ş K Özdemir, M S Tame   +3 more
doaj   +1 more source

On multiplexing in physical random number generation, and conserved total entropy content. [PDF]

Sci Rep, 2023
Monet F, Kashyap R.
europepmc   +1 more source