Results 41 to 50 of about 118,611,904 (228)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A horadam-based pseudo-random number generator [PDF]

, 2014
Uniformly distributed pseudo-random number generators are commonly used in certain numerical algorithms and simulations. In this article a random number generation algorithm based on the geometric properties of complex Horadam sequences was investigated.
Chen, M., Bagdasar, O.D., Bagdasar, O.
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Numerical simulation of bubble generation in a T-junction [PDF]

, 2012
We present a numerical study of the formation of mini-bubbles in a 2D T-junction by means of the fluid dynamics numerical code JADIM. Numerical simulations were carried out for different flow conditions, giving rise to results on the behavior of bubble ...
S. Arias, D. Legendre, Arias, Santiago, R. González-Cinca, Legendre, Dominique, Gonzales-Cinca, Ricardo   +5 more
core   +1 more source

Comparing Basic ML Algorithms for Classifying Allusive vs. Non-Allusive Persian Poetry [PDF]

̒Ilm-i Zabān
The present study aims to evaluate the performance of several machine learning methods in classifying Persian poetry into two categories: verses containing allusion and those without allusion.
Parisa Mohammadian Kalkhoran, Mohammad Bahrani   +1 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Entropy generation and heatline visualization of magnetized thermal convection in an irregular enclosure filled with nanofluid and subject to non-uniform heating: FEM-machine learning hybrid approach

Case Studies in Thermal Engineering
This investigation's primary objective is to analyze the fluid dynamics and heat transfer enhancement in an irregular enclosure. Several physical phenomena such as Alumina-water nanofluids, magnetic field, non-uniform heating and amplitude of non-uniform
Hasan Shahzad, Zhiyong Li, Tingting Tang, Yongyu Xie, Zhuobin Lin   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Efficient approximation of random fields for numerical applications [PDF]

, 2014
This article is dedicated to the rapid computation of separable expansions for the approximation of random fields. We consider approaches based on techniques from the approximation of non-local operators on the one hand and based on the pivoted Cholesky ...
Michael Peters, Markus Siebenmorgen, Peters, Michael, Helmut Harbrecht, Siebenmorgen, Markus, Harbrecht, Helmut   +5 more
core   +1 more source

Aerodynamic Optimization of Transonic High-Pressure Turbine Vanes with Non-Axisymmetric Endwalls for Rotating Detonation Engines

International Journal of Turbomachinery, Propulsion and Power
For coupling a transonic high-pressure turbine vane with a rotating detonation combustor, several integration approaches have been considered. Endwall diffusion in the vane row can facilitate coupling by enabling a higher turbine inlet Mach number ...
Panagiotis Gallis, Sergio Grasa, Guillermo Paniagua, Simone Salvadori, Daniela Anna Misul   +4 more
doaj   +1 more source