Results 51 to 60 of about 71,371 (245)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Hardware Generator of Multi-point Distributed Random Numbers for Monte Carlo Simulation [PDF]

Monte Carlo simulation of weak approximations of stochastic differential equations constitutes an intensive computational task. In applications such as finance, for instance, to achieve "real time" execution, as often required, one needs highly efficient
Filippo Martini, Nicola Bruti-Liberati, Massimo Piccardi, Eckhard Platen   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Portable random number generators [PDF]

Computers are deterministic devices, and a computer-generated random number is a contradiction in terms. As a result, computer-generated pseudorandom numbers are fraught with peril for the unwary. We summarize much that is known about the most well-known
Gerald P. Dwyer, Jr., K. B. Williams
core  

Particle-Based Modeling of Ni-YSZ Anodes [PDF]

, 2012
In this work we examine the performance of particle-based models with respect to the Ni-YSZ composite anode system. The conductivity and triple-phase boundary (tpb) of particle-based systems is estimated.
Thomas, Vaughan Lamar
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Parallel Computation in Econometrics: A Simplified Approach [PDF]

Parallel computation has a long history in econometric computing, but is not at all wide spread. We believe that a major impediment is the labour cost of coding for parallel architectures.
Neil Shephard, Jurgen A. Doornik, David F. Hendry   +2 more
core  

DETERMINATION OF PARAMETER-LIMITED ESTIMATES OF EXTREME VALUE DISTRIBUTIONS AND MODELING OF CONDITIONS FOR THEIR OCCURRENCE USING STATGRAPHICS AND MATLAB

Сучасні інформаційні системи
Research objective is to estimate the parameters of extreme value distribution laws constrained by parameters using the maximum likelihood method and to model the conditions of their occurrence with STATGRAPHICS and MATLAB tools.
Svitlana Gadetska , Valeriy Dubnitskiy , Yuri Kushneruk , Yuriy Ponochovnyi , Alexander Khodyrev   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Comparative Numerical Analysis of MSGDTM and Jacobi Spectral Collocation Methods for a Fractional-Order Computer Virus Model

Journal of Mathematics
This paper presents a new fractional-order model that captures the propagation dynamics of computer viruses within digital networks by incorporating memory effects and nonlocal interactions via the Caputo derivative.
Ghaliah Alhamzi, Mona Bin-Asfour, Mehmet Yavuz, Emad Solouma, Ali Sarrah, Sayed Saber   +5 more
doaj   +1 more source