Results 31 to 40 of about 118,611,904 (228)

Numerical methods for boundary value problems on random domains [PDF]

, 2014
In this thesis, we consider the numerical solution of elliptic boundary value problems on random domains. The underlying domain is modelled via a random vector field which is given by its mean and its covariance.
Peters, Michael
core   +1 more source

An Efficient Method for Generating a Super-Sized and Heterogeneous Pore-Throat Network Model of Rock

Applied Sciences
The super-sized pore-throat network model can reflect both microscopic pore characteristics and macroscopic heterogeneity and is excellent in describing cross-scale flow fields.
Chunlei Yu, Wenbin Chen, Junjian Li, Shuoliang Wang   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating the tensile cracking mechanisms of rock masses containing random fissures from the perspective of meshless numerical method

Frontiers in Earth Science
This paper focuses on the tensile cracking mechanisms of rock masses containing random fissures and conducts research based on the meshless numerical method.
Jinyu Chen, Yi Sun, Yi Sun, Wei Li, Bufan Zhang, Shuyang Yu   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Configurable cellular automata for pseudorandom number generation [PDF]

, 2005
This paper proposes a generalized structure of cellular automata (CA) – the configurable cellular automata (CoCA). With selected properties from programmable CA (PCA) and controllable CA (CCA), a new approach to cellular automata is developed.
Guan, SU, Quieta, M.T., Quieta, MT, Guan, S.-U.   +3 more
core   +1 more source

Analysis of an Improved Circuit for Laser Chaos and Its Synchronization

IEEE Access
The exploration of chaos, synchronization, and circuit implementation in analog simulations unveils a versatile framework with diverse applications. Originating from a universal chaos model rooted in laser physics, its adaptability extends to neural ...
Roberto Concas, Alessio Montori, Eugenio Pugliese, Alessio Perinelli, Leonardo Ricci, Riccardo Meucci   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source