Results 71 to 80 of about 439,273 (266)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Pseudo Random Coins Show More Heads Than Tails

, 2004
Tossing a coin is the most elementary Monte Carlo experiment. In a computer the coin is replaced by a pseudo random number generator. It can be shown analytically and by exact enumerations that popular random number generators are not capable of ...
Bauke, Heiko, Mertens, Stephan
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Errors in Monte Carlo simulations using shift register random number generators

, 1995
We report large systematic errors in Monte Carlo simulations of the tricritical Blume-Capel model using single spin Metropolis updating. The error, manifest as a $20\%$ asymmetry in the magnetisation distribution, is traced to the interplay between ...
Schmid, F., Wilding, N. B.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Superconducting Nanostrip Photon-Number-Resolving Detector as an Unbiased Random Number Generator

IEEE Transactions on Quantum Engineering
Detectors capable of resolving the number of photons are essential in many applications, ranging from classic photonics to quantum optics and quantum communication.
Pasquale Ercolano, Mikkel Ejrnaes, Ciro Bruscino, Syed Muhammad Junaid Bukhari, Daniela Salvoni, Chengjun Zhang, Jia Huang, Hao Li, Lixing You, Loredana Parlato, Giovanni Piero Pepe   +10 more
doaj   +1 more source

A random number generator for continuous random variables [PDF]

A FORTRAN 4 routine is given which may be used to generate random observations of a continuous real valued random variable.
Guerra, V. M., Tapia, R. A., Thompson, J. R.   +2 more
core   +1 more source

Properties making a chaotic system a good Pseudo Random Number Generator

, 2005
We discuss two properties making a deterministic algorithm suitable to generate a pseudo random sequence of numbers: high value of Kolmogorov-Sinai entropy and high-dimensionality.
A. N. Kolmogorov, A. N. Kolmogorov, Angelo Vulpiani, B. F. Green, B. V. Chirikov, D. E. Knuth, E. Ott, F. Takens, G. Marsaglia, H. D. I. Abarbanel, H. Kantz, J. Coste, J. Von Neumann, Luigi Palatella, Massimo Falcioni, R. R. Coveyou, Simone Pigolotti, V. I. Arnol’d   +17 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Non-Recurring Improved Random Number Generator- a new step to improve cryptographic algorithms

EAI Endorsed Transactions on Energy Web, 2018
The world is now behind technology transforming every terminology in daily life, like banking, cash, paper, shopping, communication and so on into, e-world terminologies.
Thomas Antu Annam, Paul Varghese
doaj   +1 more source