Results 71 to 80 of about 71,987 (254)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
IEEE Access, 2018 The key point of cryptography is cryptographic algorithms and keys. The random number generator is used to generate seeds and keys randomly in many cryptographic systems.
Kyungroul Lee +3 more
doaj +1 more source
A Hardware Random Number Generator [PDF]
, 2003 Some of the desirable properties a cryptographic random number generator should have are lack of bias, bit independence, unpredictiability and nonrepeatability. In this paper, we discuss how a hardware random number generator formed from simple components can provide these properties. The components include two state machines with different structures,
openaire +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Stochastic methods of information security
Безопасность информационных технологийComputer systems (CS) security has become a very critical concern that needs the attention of researchers to ensure the information protection and cyber security.
Mikhail A. Ivanov
doaj +1 more source
Random Number Generator Untuk Bobot Metode Conjugate Gradient Neural Network
Jurnal Derivat, 2017 This research develops the theory of NN (neural network) by using CG (conjugate gradient) to speed up the process of convergence on a network of NN. CG algorithm is an iterative algorithm to solve simultaneous linear equations on a large scale and it is ...
Yudistira Arya Sapoetra +2 more
doaj +1 more source
Accuracy in random number generation [PDF]
Mathematics of Computation, 1985 The generation of continuous random variables on a digital computer encounters a problem of accuracy caused by approximations and discretization error. These in turn impose a bias on the simulation results. An ideal discrete approximation of a continuous distribution and a measure of error are proposed.
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source