Results 141 to 150 of about 20,745 (303)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Pseudorandom number generation on supercomputers
Random Walks;Supercomputer;computer ...
Adams, N., Kleijnen, J.P.C.
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Uniform Random Number Generators [PDF]
1998 Winter Simulation Conference. Proceedings (Cat. No.98CH36274), 2002 openaire +1 more source
On randomness of random number generators
, 1989 Many computer simulations use random number generators and since most computer languages have a built-in generator it is very easy just to use that one.
Verhaegh, WFJ Wim
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Random Number Generators for Cryptography
, 2016 International audienceRandom number generators (RNGs) are computational or physical functions generating a sequence of bits or symbols (e.g. groups of bits - numbers) that do not feature any pattern - generated bits or symbols (numbers) are independent ...
Haddad, Patrick, Fischer, Viktor
core +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Random number generators for parallel computers
, 1996 Random number generators are used in many applications, from slot machines to simulations of nuclear reactors. For many computational science applications, such as Monte Carlo simulation, it is crucial that the generators have good randomness properties.
Paul D. Coddington, Coddington, Paul D.
core
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source