Results 121 to 130 of about 20,745 (303)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Some Difficult-to-pass Tests of Randomness

open access: yes
We describe three tests of randomness-- tests that many random number generators fail. In particular, all congruential generators-- even those based on a prime modulus-- fail at least one of the tests, as do many simple generators, such as shift register
George Marsaglia, Wai Wan Tsang
core  

Random Number Generators

open access: yes, 2014
Article published in Mathematics Exchange, 9(1), 2014.From simple gambling thousands of years ago, to modern statistical sampling, humans have created random number generators.
Turner, Hannah, Dibble, Chris
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Comparative Study of ASE-ASE and ASE-Laser Based Quantum Random Number Generators

open access: yesIEEE Photonics Journal
Quantum random number generators (QRNG) based on amplified spontaneous emission (ASE) are known to achieve multi-gigabit-per-second rates through high-speed sampling of intensity and phase fluctuations.
Shreyam Maity   +4 more
doaj   +1 more source

Random Number Generators

open access: yes, 1993
This paper is about pseudo-random number generators. In particular it is about pseudo-random number generators for the 16 bit computers. These machines include the IBM PC, XT, and AT. Thus this class comprises a large share of the PC market.
Sieben, John Thomas
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Pseudorandom number generation with self programmable cellular automata

open access: yes, 2004
In this paper, we propose a new class of cellular automata – self programming cellular automata (SPCA) with specific application to pseudorandom number generation. By changing a cell's state transition rules in relation to factors such as its neighboring
Guan, SU, Tan, SK
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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