Results 161 to 170 of about 6,728 (248)

Advanced Experiment Design Strategies for Drug Development

open access: yesAdvanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang   +3 more
wiley   +1 more source

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2924-2936, August 2026.
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen   +8 more
wiley   +1 more source

Environmental and local habitat variables as predictors of trophic interactions in subtidal rocky reefs along the SE Pacific coast

open access: yesEcography, Volume 2026, Issue 8, August 2026.
Temperature generally drives latitudinal patterns in the strength of trophic interactions, including consumption rates. However, local community and other environmental conditions might also affect consumption, disrupting latitudinal gradients, which results in complex large‐scale patterns.
Catalina A. Musrri   +6 more
wiley   +1 more source

Calibration of Retrospective and Prospective Life Satisfaction Judgments Around the World

open access: yesFUTURES &FORESIGHT SCIENCE, Volume 8, Issue 2, August 2026.
ABSTRACT It is both a physical and psychological fact that humans have access to records of the past but not to records of the future. Due to this epistemic asymmetry in time, we hypothesized that retrospection about past psychological states will be better calibrated than prospection about future psychological states.
David R. Mandel   +2 more
wiley   +1 more source

Revisiting EWMA in High‐Frequency‐Based Portfolio Optimization: A Comparative Assessment

open access: yesJournal of Applied Econometrics, Volume 41, Issue 5, Page 523-538, August 2026.
ABSTRACT This paper compares the statistical and economic performance of state‐of‐the‐art high‐frequency (HF) based multivariate volatility models with a simpler, widely used alternative, the Exponentially Weighted Moving Average (EWMA) filter. Using over two decades of 100 U.S.
Laura Capera Romero, Anne Opschoor
wiley   +1 more source

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