Results 51 to 60 of about 2,148,018 (281)

Random Forest Weighted Local Fréchet Regression with Random Objects

, 2022
Statistical analysis is increasingly confronted with complex data from metric spaces. Petersen and Müller (2019) established a general paradigm of Fréchet regression with complex metric space valued responses and Euclidean predictors. However, the local approach therein involves nonparametric kernel smoothing and suffers from the curse of ...
Qiu, Rui, Yu, Zhou, Zhu, Ruoqing
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Genetics of heat tolerance for milk yield and quality in Holsteins

Animal, 2017
Tropical and sub-tropical climates are characterized by high temperature and humidity, during at least part of the year. Consequently, heat stress is common in Holstein cattle and productive and reproductive losses are frequent.
M.L. Santana, Jr, A.B. Bignardi, R.J. Pereira, G. Stefani, L. El Faro   +4 more
doaj   +1 more source

Shape restricted regression with random Bernstein polynomials

, 2007
Shape restricted regressions, including isotonic regression and concave regression as special cases, are studied using priors on Bernstein polynomials and Markov chain Monte Carlo methods.
Chang, I-Shou, Chien, Li-Chu, Hsiung, Chao A., Wen, Chi-Chung, Wu, Yuh-Jenn   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Analyses of growth curves of Nellore cattle by Bayesian method via Gibbs sampling

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2003
Growth curves of Nellore cattle were analyzed using body weights measured at ages ranging from 1 day (birth weight) to 733 days. Traits considered were birth weight, 10 to 110 days weight, 102 to 202 days weight, 193 to 293 days weight, 283 to 383 days ...
P.R.C. Nobre, P.S. Lopes, R.A. Torres, L.O.C. Silva, A.J. Regazzi, R.A.A. Torres Júnior, I. Misztal   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Genotype × environment interaction in milk traits of Guzerá cattle using reaction norm models [PDF]

Revista Brasileira de Zootecnia
This study aimed to evaluate genotype × environment (G×E) interactions in Guzerá breed animals for 305-day first-lactation cumulative yields (kg) of milk (MY305), fat (FY305), and protein (PY305). We used 6823 records of MY305, 2466 records of FY305, and
Tainara Luana da Silva Soares, Maria Gabriela Campolina Diniz Peixoto, Eula Regina Carrara, Delvan Alves da Silva, Fernanda Larissa Cesar Santos, Frank Angelo Tomita Bruneli, Renata Veroneze, Paulo Sávio Lopes   +7 more
doaj   +1 more source