Results 81 to 90 of about 6,730,982 (293)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Surface-Restructuring Differences between Polyrotaxanes and Random Copolymers in Aqueous Environment

open access: yes, 2018
In the present study, we investigated the surface reorganization behaviors and adsorption conformations of fibrinogen on the surface of polyrotaxanes containing different amounts of α-cyclodextrin (α-CD) by using surface-sensitive vibrational ...
Aimin Ge   +9 more
core   +1 more source

Three-dimensional correlation of speckles in deep Fresnel region: extracting the roughness exponent of random surface

open access: yesNew Journal of Physics, 2019
We provide a detailed analysis of the three-dimensional cross correlation properties of speckle patterns in the deep Fresnel region scattered by random surface.
Chunxiang Liu   +7 more
doaj   +1 more source

Simulating multi-fractal sea clutter and surface based on the random multiplicative model

open access: yesThe Journal of Engineering, 2019
It has been proved that the multi-fractal sea clutter can be simulated by the three-partitioned random multiplicative model. This study constructs multi-fractal sequences with similar multiplicative factors of the sea clutter of the IPIX radar and ...
Caiping Xi   +3 more
doaj   +1 more source

Equilibrium Adsorption on a Random Site Surface

open access: yesThe Journal of Physical Chemistry B, 2008
10 Pages, 11 ...
Talbot, J., Tarjus, G., Viot, P.
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Random lasing of microporous surface of Cr2+:ZnSe crystal induced by femtosecond laser

open access: yesAIP Advances, 2015
We demonstrate a random lasing emission based on microporous surface of Cr2+:ZnSe crystal prepared by femtosecond pulsed laser ablation in high vacuum (below 5 × 10−4 Pa).
Xianheng Yang   +5 more
doaj   +1 more source

RENORMALIZATION OF COUPLINGS IN EMBEDDED RANDOM SURFACES

open access: yesModern Physics Letters A, 1992
We study the dressing of operators and flows of corresponding couplings in models of embedded random surfaces. We show that these dressings can be obtained by applying the methods of David and Distler and Kawai. We consider two extreme limits. In the first limit the string tension is large and the dynamics is dominated by the Nambu-Goto term.
Das, Sumit R., Rama, S. Kalyana
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy