Results 41 to 50 of about 249,007 (264)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A new generation tree for permutations, preserving the number of fixed points [PDF]
Discrete Mathematics & Theoretical Computer Science, 2014 We describe a new uniform generation tree for permutations with the specific property that, for most permutations, all of their descendants in the generation tree have the same number of fixed points.
Philippe Duchon, Romaric Duvignau
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Acta Mathematica Hungarica, 2013 Local convergence of bounded degree graphs was introduced by Benjamini and Schramm. This result was extended further by Lyons to bounded average degree graphs. In this paper, we study the convergence of a random tree sequence where the probability of a given tree is proportional to $\prod_{v_i\in V(T)}d(v_i)!$.
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
International Journal of Advanced Robotic Systems, 2019 The path planning for an Unmanned Aerial Vehicles ensures that a dynamically feasible and collision-free path is planned between a start and an end point within a navigation environment.
Luiz GDO Véras +2 more
doaj +1 more source
DPRF: A Differential Privacy Protection Random Forest
IEEE Access, 2019 Providing privacy protection for classification algorithms has become a research hotspot in current data mining. In this paper, differential privacy is applied to the random forest classification algorithm, and a random forest algorithm based on ...
Jun Hou +5 more
doaj +1 more source
Improved Bidirectional RRT* Algorithm for Robot Path Planning
Sensors, 2023 In order to address the shortcomings of the traditional bidirectional RRT* algorithm, such as its high degree of randomness, low search efficiency, and the many inflection points in the planned path, we institute improvements in the following directions.
Peng Xin +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source