Results 61 to 70 of about 258,206 (308)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ferromagnetic Ising spin systems on the growing random tree [PDF]

, 2009
We analyze the ferromagnetic Ising model on a scale-free tree; the growing random tree model with the linear attachment kernel A_k=k+α. We derive an estimate of the divergent temperature T_s below which the zero-field susceptibility of the system ...
Hasegawa, Takehisa, Nemoto, Koji
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Rapidly exploring Random Tree* with a sampling method based on Sukharev grids and convex vertices of safety hulls of obstacles

International Journal of Advanced Robotic Systems, 2019
The path planning for an Unmanned Aerial Vehicles ensures that a dynamically feasible and collision-free path is planned between a start and an end point within a navigation environment.
Luiz GDO Véras, Felipe LL Medeiros, Lamartine NF Guimarães   +2 more
doaj   +1 more source

DPRF: A Differential Privacy Protection Random Forest

IEEE Access, 2019
Providing privacy protection for classification algorithms has become a research hotspot in current data mining. In this paper, differential privacy is applied to the random forest classification algorithm, and a random forest algorithm based on ...
Jun Hou, Qianmu Li, Shunmei Meng, Zhen Ni, Yini Chen, Yaozong Liu   +5 more
doaj   +1 more source

Improved Bidirectional RRT* Algorithm for Robot Path Planning

Sensors, 2023
In order to address the shortcomings of the traditional bidirectional RRT* algorithm, such as its high degree of randomness, low search efficiency, and the many inflection points in the planned path, we institute improvements in the following directions.
Peng Xin, Xiaomin Wang, Xiaoli Liu, Yanhui Wang, Zhibo Zhai, Xiqing Ma   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Rapidly Exploring Random Tree Funnel Algorithm

, 2022
This paper shows the feasibility of combining robust motion primitives generated through the Sums Of Squares programming theory with a discrete Rapidly exploring Random Tree algorithm.
Orhagen, Ole Petter, Thoresen, Marius, Mathiassen, Kim   +2 more
core  

Multilevel Nonlinear Mixed-Effect Crown Ratio Models for Individual Trees of Mongolian Oak (Quercus mongolica) in Northeast China. [PDF]

PLoS ONE, 2015
In this study, an individual tree crown ratio (CR) model was developed with a data set from a total of 3134 Mongolian oak (Quercus mongolica) trees within 112 sample plots allocated in Wangqing Forest Bureau of northeast China.
Liyong Fu, Huiru Zhang, Jun Lu, Hao Zang, Minghua Lou, Guangxing Wang   +5 more
doaj   +1 more source

Konsep Decision Tree Reptree untuk Melakukan Optimasi Rule dalam Fuzzy Inference System Tsukamoto

Jurnal Teknologi Informasi dan Ilmu Komputer, 2022
Penelitian ini menjelaskan tentang decision tree REPTree dalam membuat suatu rule yang terbentuk dari produksi minyak kelapa sawit di PT Tapiana Nadenggan, yang dipengaruhi oleh faktor banyaknya kelapa sawit, permintaan yang ada, serta persediaan yang ...
Tundo Tundo, Shofwatul 'Uyun
doaj   +1 more source