Results 71 to 80 of about 5,901,134 (247)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Bounds and approximations for sums of dependent log-elliptical random variables. [PDF]
Dhaene, Denuit, Goovaerts, Kaas and Vyncke [Dhaene, J., Denuit, M., Goovaerts, M.J., Kaas, R., Vyncke,D., 2002a. The concept of comonotonicity in actuarial science and finance: theory. Insurance Math.Econom.
Mateusz, Maj +3 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The proposal of explicit account of the random character of design process parameters
Budownictwo i Architektura, 2013 The study concerns the static analysis of rods structures in terms of probabilism. Structural design parameters are defined as the deterministic values and random variables. Random variables are not correlated.
Agnieszka Dudzik, Urszula Radoń
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Comparing approximations for risk measures of sums of non-independent lognormal random variables. [PDF]
In this paper, we consider different approximations for computing the distribution function or risk measures related to a sum of non-independent lognormal random variables.
Hoedemakers, Tom +2 more
core
The uncertainty evaluation method of supply chain reliability [PDF]
Transport, 2009 The objective of the article is to scientifically evaluate supply chain reliability (SCR). We argue that this problem relates to two aspects - the cognition and expression of SCR.
X. Miao, B. Yu, B. Xi
doaj +2 more sources
Symbulate: Simulation in the Language of Probability
Journal of Statistics Education, 2019 Simulation is an effective tool for analyzing probability models as well as for facilitating understanding of concepts in probability and statistics. Unfortunately, implementing a simulation from scratch often requires users to think about programming ...
Kevin Ross, Dennis L. Sun
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source