Results 101 to 110 of about 4,476,990 (351)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Doubly stochastic continuous time random walk

open access: yesPhysical Review Research
Since its introduction some 60 years ago, the Montroll-Weiss continuous time random walk has found numerous applications due its ease of use and ability to describe both regular and anomalous diffusion. Yet, despite its broad applicability and generality,
Maxence Arutkin, Shlomi Reuveni
doaj   +1 more source

Link prediction using discrete-time quantum walk

open access: yesTehnički Vjesnik, 2017
Link prediction is one of the key issues of complex networks, which attracts much research interest currently. Many link prediction methods have been proposed so far.
Jing Qian   +3 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

The Speed of Simple Random Walk and Anchored Expansion on Percolation Clusters: an Overview [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2003
Benjamini, Lyons and Schramm (1999) considered properties of an infinite graph $G$, and the simple random walk on it, that are preserved by random perturbations.
Dayue Chen, Yuval Peres
doaj   +1 more source

Incorporating Vector Space Similarity in Random Walk Inference over Knowledge Bases

open access: yesConference on Empirical Methods in Natural Language Processing, 2014
Much work in recent years has gone into the construction of large knowledge bases (KBs), such as Freebase, DBPedia, NELL, and YAGO. While these KBs are very large, they are still very incomplete, necessitating the use of inference to fill in gaps.
Matt Gardner   +3 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Random walk models in biology

open access: yesJournal of the Royal Society Interface, 2008
Mathematical modelling of the movement of animals, micro-organisms and cells is of great relevance in the fields of biology, ecology and medicine. Movement models can take many different forms, but the most widely used are based on the extensions of ...
Edward A. Codling, M. Plank, S. Benhamou
semanticscholar   +1 more source

Bootstrap random walks

open access: yesStochastic Processes and their Applications, 2016
Consider a one dimensional simple random walk $X=(X_n)_{n\geq0}$. We form a new simple symmetric random walk $Y=(Y_n)_{n\geq0}$ by taking sums of products of the increments of $X$ and study the two-dimensional walk $(X,Y)=((X_n,Y_n))_{n\geq0}$. We show that it is recurrent and when suitably normalised converges to a two-dimensional Brownian motion with
Andrea Collevecchio   +2 more
openaire   +3 more sources

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