Results 81 to 90 of about 125,107 (311)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

A New Random Walk for Replica Detection in WSNs. [PDF]

open access: yesPLoS ONE, 2016
Wireless Sensor Networks (WSNs) are vulnerable to Node Replication attacks or Clone attacks. Among all the existing clone detection protocols in WSNs, RAWL shows the most promising results by employing Simple Random Walk (SRW).
Mohammed Y Aalsalem   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Random-walk behavior along task-irrelevant dimensions. [PDF]

open access: yes, 2019
In A), B), C), we show that our learning model predicts that updating aim based on reinforcement feedback can lead to random-walk behaviour along task-irrelevant dimensions.
Susan K. Coltman (6421388)   +5 more
core   +1 more source

Random-walk enzymes

open access: yesPhysical Review E, 2015
Enzymes that rely on random walk to search for substrate targets in a heterogeneously dispersed medium can leave behind complex spatial profiles of their catalyzed conversions. The catalytic signatures of these random-walk enzymes are the result of two coupled stochastic processes: scanning and catalysis. Here we develop analytical models to understand
Chi H, Mak   +3 more
openaire   +3 more sources

Hipster random walks

open access: yesProbability Theory and Related Fields, 2020
We introduce and study a family of random processes on trees we call hipster random walks, special instances of which we heuristically connect to the min-plus binary trees introduced by Robin Pemantle and studied by Auffinger and Cable (2017; arXiv:1709.07849), and to the critical random hierarchical lattice studied by Hambly and Jordan (2004).
L. Addario-Berry   +4 more
openaire   +3 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

Angular asymptotics for multi-dimensional non-homogeneous random walks with asymptotically zero drift [PDF]

open access: yes, 2009
We study the rst exit time from an arbitrary cone with apex at the origin by a non-homogeneous random walk (Markov chain) on Zd (d 2) with mean drift that is asymptotically zero.
MacPhee, Iain M.   +7 more
core   +1 more source

rougier/random-walk: Version 1.1 [PDF]

open access: yes, 2017
Re-run, Repeat, Reproduce, Replicate, Re ...
Fabien C. Y. Benureau   +1 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

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