Results 51 to 60 of about 124,658 (311)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The random walk Metropolis : linking theory and practice through a case study. [PDF]

, 2009
The random walk Metropolis (RWM) is one of the most common Markov Chain Monte Carlo algorithms in practical use today. Its theoretical properties have been extensively explored for certain classes of target, and a number of results with important ...
Fearnhead, Paul, Chris Sherlock, Sherlock, Chris, Paul Fearnhead, Roberts, Gareth, Roberts, Gareth O., Gareth O. Roberts   +6 more
core   +1 more source

Lengths and heights of random walk excursions [PDF]

Discrete Mathematics & Theoretical Computer Science, 2003
Consider a simple symmetric random walk on the line. The parts of the random walk between consecutive returns to the origin are called excursions. The heights and lengths of these excursions can be arranged in decreasing order.
Endre Csáki, Yueyun Hu
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

SARW: Similarity-Aware Random Walk for GCN

, 2023
Graph Convolutional Network (GCN) is an important method for learning graph representations of nodes. For large-scale graphs, the GCN could meet with the neighborhood expansion phenomenon, which makes the model complexity high and the training time long.
Wu, Ou, Guo, Alan J.X., Hou, Linlin, Zhang, Ji, Yua, Ting, Zhang, Haixiang, Hou, Qing-Hu   +6 more
core   +1 more source

Random Walks in Random Environment [PDF]

Journal of Physics A: Mathematical and General, 2006
Random walks in random environments (RWRE's) have been a source of surprising phenomena and challenging problems since they began to be studied in the 70's. Hitting times and, more recently, certain regeneration structures, have played a major role in our understanding of RWRE's. We review these and provide some hints on current research directions and
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Noisy cyclic quantum random walk

APL Quantum
We explore static noise in a discrete quantum random walk over a homogeneous cyclic graph, focusing on the spectral and dynamical properties of the system.
Gilberto Juárez Rangel, Blas Manuel Rodríguez-Lara   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Edge reinforced random walk on Galton-Watson trees

, 2023
reservedConsider a random walk in a graph and introduce a reinforcement on the edges so that the ones already traversed are more likely to be traversed in the future. We call such a process edge reinforced random walk (ERRW).
CARLON, GIOVANNI
core